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Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophreniaExpand
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A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: suggestive evidence for linkage on chromosomes 7p and 15q.
A genome scan was performed on 164 Dutch affected sib pairs (ASPs) with attention-deficit/hyperactivity disorder (ADHD). All subjects were white and of Dutch descent and were phenotyped according toExpand
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Healthy individuals with auditory verbal hallucinations; who are they? Psychiatric assessments of a selected sample of 103 subjects.
Epidemiological studies suggest that auditory verbal hallucinations (AVH) occur in approximately 10%-15% of the general population, of whom only a small proportion has a clinically relevant psychoticExpand
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Region and state specific glutamate downregulation in major depressive disorder: A meta-analysis of 1H-MRS findings
For major depressive disorder (MDD), magnetic resonance spectroscopy ((1)H-MRS) studies of glutamate, glutamine and Glx (the composite measure of mainly glutamate and glutamine) have yieldedExpand
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An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia
Several lines of evidence, including expression analyses, brain imaging and genetic studies suggest that the integrity of myelin is disturbed in schizophrenia patients. In this study, we firstExpand
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A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy.
Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune uveitis that can lead to severe visual impairment. Intriguingly, >95% of cases carry the HLA-A29 allele, which defines the strongestExpand
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The PIP5K2A and RGS4 genes are differentially associated with deficit and non‐deficit schizophrenia
Several putative schizophrenia susceptibility genes have recently been reported, but it is not clear whether these genes are associated with schizophrenia in general or with specific diseaseExpand
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Effects of brain‐derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia
A functional polymorphism of the brain‐derived neurotrophic factor (BDNF) gene (Val66Met) has been associated with the risk for schizophrenia and volume differences in the hippocampus. However,Expand
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Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial forExpand
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DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families
Recent meta‐analyses have indicated that the dopamine transporter gene (DAT1) and the dopamine receptor genes D4 (DRD4) and D5 (DRD5) are associated with attention‐deficit hyperactivity disorderExpand
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