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The hormone resistin links obesity to diabetes
TLDR
It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Expand
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
TLDR
The studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways. Expand
Nucleosome Dynamics Define Transcriptional Enhancers
Chromatin plays a central role in eukaryotic gene regulation. We performed genome-wide mapping of epigenetically marked nucleosomes to determine their position both near transcription start sites andExpand
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response.
  • C. Su, X. Wen, +7 authors G. D. Wu
  • Biology, Medicine
  • The Journal of clinical investigation
  • 15 August 1999
TLDR
It is reported here that PPAR-gamma ligands dramatically attenuate cytokine gene expression in colon cancer cell lines by inhibiting the activation of nuclear factor-kappaB via an IkappaB-alpha-dependent mechanism, and thiazolidinedione ligands for PPARS markedly reduce colonic inflammation in a mouse model of IBD. Expand
Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ*
TLDR
It is reported here that PGF2α blocks adipogenesis through activation of mitogen-activated protein kinase, resulting in inhibitory phosphorylation of PPARγ, a nuclear hormone receptor that is central to adipogenic determination. Expand
Targeting androgen receptor in estrogen receptor-negative breast cancer.
TLDR
Analysis of the AR cistrome and androgen-regulated gene expression in ER-/HER2+ breast cancers finds that AR mediates ligand-dependent activation of Wnt and HER2 signaling pathways through direct transcriptional induction of WNT7B and HER3. Expand
Interdomain communication regulating ligand binding by PPAR-γ
TLDR
The ability of the A/B domain to regulate ligand binding has important implications for the evaluation and mechanism of action of potentially therapeutic ligands that bind PPAR-γ and that are likely to extend to other members of the nuclear-receptor superfamily. Expand
A Potent Antidiabetic Thiazolidinedione with Unique Peroxisome Proliferator-activated Receptor γ-activating Properties*
TLDR
MCC-555 is characterized, a novel thiazolidinedione ligand for PPARγ with unique functional properties and the antidiabetic potency of this compound is greater than that of other TZDs, including BRL49653, yet its binding affinity forPPARγ is less than 1 10 that of BRL 49653. Expand
Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance.
TLDR
It is shown that the EGF-induced ERα genomic targets, its cistromes, are distinct from those induced by estrogen in a process dependent on the transcription factor AP-1, and this provides a potential molecular explanation for the endocrine therapy resistance seen in ERα-positive breast cancers that overexpress ERBB2. Expand
Interdomain communication regulating ligand binding by PPAR-gamma.
TLDR
The ability of the A/B domain to regulate ligand binding has important implications for the evaluation and mechanism of action of potentially therapeutic ligands that bind PPAR-gamma and that are likely to extend to other members of the nuclear-receptor superfamily. Expand
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