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Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
TLDR
It is shown that T cells that express the canonical hVα7.2-Jα33 or mVα19-J α33 TCR rearrangement are preferentially located in the gut lamina propria of humans and mice, respectively, and are therefore genuine mucosal-associated invariant T (MAIT) cells.
Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.
TLDR
A highly divergent human MHC class I molecule, MICA, encodes a cell surface glycoprotein, which is not associated with beta 2-microglobulin, is conformationally stable independent of conventional class I peptide ligands, and almost exclusively expressed in gastrointestinal epithelium.
A second lineage of mammalian major histocompatibility complex class I genes.
TLDR
A second lineage of evolutionarily conserved MHC class I genes is defined and the presence of diagnostic residues in the MICA amino acid sequence translated from cDNA suggests that the putative MICA chain folds similarly to typical class I chains and may have the capacity to bind peptide or other short ligands.
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci
TLDR
A genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls) identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 × 10−8) and 1q32.1 (IL10, rs1554286).
Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behçet disease.
TLDR
The possibility of a primary association of Behcet disease with MICA rather than HLA-B is suggested, as the predicted amino acid sequence of the MICA chain suggests that it folds similarly to typical class I chains and may have the capacity to bind peptides or other short ligands.
Genetics of Behçet disease inside and outside the MHC
TLDR
This genome-wide association study of Behçet disease highlights the premier genetic susceptibility locus for BD as the major histocompatibility complex itself, wherein reside two independent loci: HLA-B and Hla-A.
Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence
Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other (≈6 million years ago), the molecular basis of traits unique to humans vs. their
A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.
TLDR
Human RAET1 products are all devoid of the membrane-proximal immunoglobulin-like alpha3 domain and most, but not all, are predicted to remain membrane-anchored via glycosylphosphatidylinositol linkage and are shown to display an atypical pattern of polymorphism.
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