• Publications
  • Influence
Microenvironmental pH modulation in solid dosage forms.
  • S. Badawy, M. Hussain
  • Materials Science, Engineering
    Journal of pharmaceutical sciences
  • 1 May 2007
TLDR
Microenvironmental pH modulation was shown to control the dissolution profile of both immediate and controlled release dosage forms of compounds with pH dependent solubility and pH modifiers have been used in conjunction with high energy or salt forms in immediate release formulations.
Impact of Excipient Interactions on Solid Dosage Form Stability
TLDR
Emerging aspects in terms of limitations of drug-excipient compatibility studies, emerging paradigms in accelerated stability testing, and application of mathematical modeling for prediction of drug product stability are discussed.
Molecular Basis of Crystal Morphology-Dependent Adhesion Behavior of Mefenamic Acid During Tableting
TLDR
Higher surface exposure of polar functional groups correlates with higher tendency to stick to metal surfaces and AFM tips, indicating involvement of specific polar interactions in the adhesion behavior.
Effect of different acids on solid-state stability of an ester prodrug of a IIb/IIIa glycoprotein receptor antagonist.
TLDR
Adding acids to blends containing DMP 754 and anhydrous lactose improved the stability at 40 degrees C/75% relative humidity and decreased the rate of hydrolysis of the amidine group and this effect was more pronounced with stronger acids.
Formulation of Solid Dosage Forms to Overcome Gastric pH Interaction of the Factor Xa Inhibitor, BMS-561389
TLDR
A multitier approach was successful in identifying a solid dosage form that minimizes the pH-dependent absorption of this drug candidate.
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