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Gene knockout of glycine transporter 1: characterization of the behavioral phenotype.
TLDR
Reduced expression of GlyT1 enhances hippocampal NMDAR function and memory retention and protects against an amphetamine disruption of sensory gating, suggesting that drugs which inhibit GlyT 1 might have both cognitive enhancing and antipsychotic effects.
Animal models of drug craving
TLDR
The development of animal models of drug craving will have heuristic value and allow a systematic investigation of the neurobiological mechanisms of craving, and these animal models are evaluated according to reliability and predictive validity.
Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
  • S. B. Caine, G. Koob
  • Psychology, Biology
    The Journal of pharmacology and experimental…
  • 1 July 1994
TLDR
It is suggested that benzazepine dopamine D-1 antagonists, at low doses, may attenuate the reinforcing properties of cocaine more selectively than other dopamine receptor antagonists.
Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.
TLDR
Three dopamine receptor agonists had affinities for binding to the D-3 receptor that correlated highly with their relative potencies in decreasing cocaine self-administration in the rat at doses that were not by themselves reinforcing.
The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications
TLDR
Sensorimotor gating of the startle reflex appears to have a discrete and identifiable set of neural substrates that may be important for the understanding of neuropsychiatric disorders characterized by deficient suppression or 'gating' of sensory, cognitive or motor processes.
Cocaine versus food choice procedure in rats: environmental manipulations and effects of amphetamine.
TLDR
The results suggest feasibility and utility of the choice procedure in rats and support its comparability to similar procedures used in humans and monkeys.
Nicotine-like behavioral effects of the minor tobacco alkaloids nornicotine, anabasine, and anatabine in male rodents.
TLDR
Results suggest that the minor tobacco alkaloids may substitute for the subjective effects of nicotine and attenuate withdrawal and craving without the abuse liability of nicotine.
Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists
TLDR
It is suggested that the D2 receptor is not necessary for cocaine self-administration, but this receptor subtype is involved in mechanisms that limit rates of high-dose cocaine self–administration.
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