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Evaluation of various polyethylenimine formulations for light-controlled gene silencing using small interfering RNA molecules.
Photochemical internalization (PCI) is a technology based on a photosensitizer that photochemically destabilizes endosomal membranes after illumination, resulting in the release of endocytosedExpand
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Photochemically induced gene silencing using small interfering RNA molecules in combination with lipid carriers.
Novel strategies for efficient delivery of small interfering RNA (siRNA) molecules with a potential for targeting are required for development of RNA interference (RNAi) therapeutics. Here, weExpand
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Light-induced gene expression using messenger RNA molecules.
The exploration of messenger RNA (mRNA) as a potential therapeutic regulator of gene expression has been significantly reduced by the inability of polyplexes to escape the endocytic pathway, combinedExpand
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MITF depletion elevates expression levels of ERBB3 receptor and its cognate ligand NRG1-beta in melanoma
The phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathway is frequently hyper-activated upon vemurafenib treatment of melanoma. We have here investigated the relationship between SRY-box 10Expand
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A novel photosensitizer for light-controlled gene silencing.
We here demonstrate for the first time that 5-carboxytetramethylrhodamine (TAMRA) covalently linked to nuclear localization signal (NLS)-conjugated peptide nucleic acids (PNAs) are photosensitizersExpand
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Potent gene silencing in vitro at physiological pH using chitosan polymers.
Among non-viral cationic polymers, biodegradable chitosan has during the last decade become an attractive carrier for small interference RNA (siRNA) delivery. Currently, degradation of macromoleculesExpand
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Enhancing nucleic acid delivery by photochemical internalization.
Photochemical internalization (PCI) is a method for releasing macromolecules from endosomal and lysosomal compartments. The PCI approach uses a photosensitizer that localizes to endosomal andExpand
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Evaluation of biodegradable peptide carriers for light-directed targeting.
A promising strategy for increased intracellular delivery of nucleic acids with the benefit for targeting is photochemical internalization (PCI). PCI relies on the use of a photosensitizing compoundExpand
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Light-controlled modulation of gene expression using polyamidoamine formulations.
A promising method that offers both time- and site-specific delivery of macromolecules is photochemical internalization technology (PCI). Here, we have characterized various polyamidoamine (PAMAM)Expand
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Abstract 4197: Regulators of p21 transcription in melanoma
p21(CIP1/WAF1) is a cyclin-dependent kinase inhibitor that directly inhibits the activity of cyclin E/CDK2 and cyclin D/CDK4/6 complexes and thereby functions as a regulator of cell cycleExpand