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Neuroinflammation: friend and foe for ischemic stroke
TLDR
How neuroinflammation has both beneficial as well as detrimental roles and recent therapeutic strategies to combat pathological responses are discussed and the time-dependent role of inflammatory factors could help in developing new diagnostic, prognostic, and therapeutic neuroprotective strategies for post-stroke inflammation. Expand
Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease
TLDR
It is suggested that ferulic acid has promising neuroprotective effect against degenerative changes in PD, and the protective effects are mediated through its antioxidant and anti-inflammatory properties. Expand
Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
TLDR
The present article presents a detailed review of the scientific literature which reveals the pharmacological properties of thymol and its multiple therapeutic actions against various cardiovascular, neurological, rheumatological, gastrointestinal, metabolic and malignant diseases at both biochemical and molecular levels. Expand
Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease
TLDR
Interestingly, BCP supplementation demonstrated the potent therapeutic effects against ROT-induced neurodegeneration, which was evidenced by BCP-mediated CB2 receptor activation and the fact that, prior administration of the CB2 receptors antagonist AM630 diminished the beneficial effects of BCP. Expand
β-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease
TLDR
It is demonstrated that BCP provides neuroprotection against rotenone-induced PD and the neuroprotective effects can be ascribed to its potent antioxidant and anti-inflammatory activities. Expand
Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone
TLDR
These findings are the first to show that the neuroprotective effect of nerolidol is mediated through its anti-oxidant and anti-inflammatory activities, which strongly supports its therapeutic potential for the treatment of PD. Expand
IFN-γ deficiency exacerbates experimental autoimmune neuritis in mice despite a mitigated systemic Th1 immune response
TLDR
IT deficiency exacerbates EAN via upregulating Th17 cells despite a mitigated systemic Th1 immune response, and raises a question whether IFN-γ might be protective in autoimmune demyelinating diseases. Expand
Attenuated EAN in TNF-α Deficient Mice Is Associated with an Altered Balance of M1/M2 Macrophages
TLDR
It is shown that the clinical severity of WT mice treated with anti-TNFR1 antibodies was less severe than that of the control WT mice receiving PBS, and no difference with regard to the clinical signs of EAN or inflammatory infiltration in cauda equina was seen. Expand
Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation
TLDR
The results of the present study indicate that TMQ may serve as an excellent agent alone or as adjuvant to prevent the onset and progression of myocardial injury. Expand
Cholinergic stimulation of the immune system protects against lethal infection by Salmonella enterica serovar Typhimurium
TLDR
It is reported that the specific inhibition of acetylcholinesterase (AChE) renders animals more resistant to infection by a virulent strain of Salmonella enterica serovar Typhimurium, a Gram‐negative enteric pathogen. Expand
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