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Triterpene glycosides from sea cucucmbers (holothurioidea, echinodermata). Biological activities and functions
Abstract The holothuroid triterpene glycosides have strong membranolytic action against cellular and model membranes containing Δ5-sterols as result of the formation of single-ion channels and moreExpand
Holothurins B(2), B(3), and B(4), new triterpene glycosides from mediterranean sea cucumbers of the genus holothuria.
TLDR
Three new monosulfated biosides, holothurins B(2) (1), B(3) (2), and B(4) (3), along with the previously known holothsurins A (4) and B (5) were isolated from the sea cucumber H. polii. Expand
Sea Cucumbers Triterpene Glycosides, the Recent Progress in Structural Elucidation and Chemotaxonomy
TLDR
All three families belonging to the order Aspidochirotida: Holothuriidae, Stichopodidae and Synallactidae have similar and parallel trends in evolution of the glycosides carbohydrate chains, namely from non-sulfated hexaosides to sulfated tetraosides. Expand
Anticancer Activity of Sea Cucumber Triterpene Glycosides
TLDR
Administration of solutions of some sea cucumber triterpene glycosides significantly reduces both tumor burden and metastasis and has the potential to be used as P-gp mediated MDR reversal agents in combined therapy with standard cytostatics. Expand
Differential effects of triterpene glycosides, frondoside A and cucumarioside A2‐2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells
TLDR
This work compared the effects of frondoside A and A2‐2 for cell death‐inducing capability with close attention paid to structure–activity relationships and suggested that holothurians may induce apoptosis of leukemic cells caspase‐dependently or ‐independently, depending on the Holothurian structure. Expand
The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer
TLDR
The results suggest that FrA is a promising new drug for the treatment of mCRPC, with high efficacy in human prostate cancer cells, while non‐malignant cells were less sensitive to it. Expand
Constituents of the sea cucumber Cucumaria okhotensis. Structures of okhotosides B1-B3 and cytotoxic activities of some glycosides from this species.
TLDR
Three new triterpene oligoglycosides, okhotosides B 1, B 2, and B 3, have been isolated from the sea cucumber Cucumaria okhotensis and the structures of 1- 3 were elucidated on the basis of their spectroscopic data (2D NMR and MS). Expand
Triterpene glycosides from the Far-Eastern sea cucumber Pentamera calcigera. 1. Monosulfated glycosides and cytotoxicity of their unsulfated derivatives.
Three new monosulfated triterpene glycosides, calcigerosides B (2), C(1) (3), and C(2) (4), along with the known cucumarioside G(2) (1), have been isolated from the sea cucumber Pentamera calcigera.Expand
Toxins from sea cucumbers (holothuroids): chemical structures, properties, taxonomic distribution, biosynthesis and evolution.
TLDR
There is a relationship between structures of the glycosides and taxonomic positions of corresponding animals, producers ofThese toxins are triterpene oligoglycosides having very often one or several sulfate groups in carbohydrate moieties. Expand
Hemolytic activities of triterpene glycosides from the holothurian order Dendrochirotida: some trends in the evolution of this group of toxins.
TLDR
The results correlate with the previously proposed trends in evolution of sea cucumber glycosides from substances having sulfate groups at C-6 of glucose and 3-O-methylglucose units to substances sulfated atC-4 of the first xylose or having no sulfategroups, and from substances with aglycone 16-ketone to substances having no oxygen functions in this position. Expand
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