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p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation.
Vascular endothelial-cadherin (VE-cad) is localized to adherens junctions at endothelial cell borders and forms a complex with alpha-, beta-, gamma-, and p120-catenins (p120). We previously showedExpand
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Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium
The nuclear receptor family member constitutive activated receptor (CAR) is activated by structurally diverse drugs and environmentally-relevant chemicals leading to transcriptional regulation ofExpand
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Neutrophil Recruitment under Shear Flow: It's All about Endothelial Cell Rings and Gaps
Leukocyte recruitment to tissues and organs is an essential component of host defense. The molecular mechanisms controlling this process are complex and remain under active investigation. TheExpand
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Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat.
  • M. Fielden, A. Adai, +14 authors B. Car
  • Medicine, Biology
  • Toxicological sciences : an official journal of…
  • 1 November 2011
Evaluating the risk of chemical carcinogenesis has long been a challenge owing to the protracted nature of the pathology and the limited translatability of animal models. Although numerous short-termExpand
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Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data
Background: Diabetes and obesity are major threats to public health in the United States and abroad. Understanding the role that chemicals in our environment play in the development of theseExpand
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Adverse events in children implanted with ventricular assist devices in the United States: Data from the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS).
BACKGROUND Ventricular assist devices (VADs) have been used in children on an increasing basis in recent years. One-year survival rates are now >80% in multiple reports. In this report we describeExpand
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BNP Levels Predict Outcome in Pediatric Heart Failure Patients: Post Hoc Analysis of the Pediatric Carvedilol Trial
Background—The ability of serum B-type natriuretic peptide levels (BNP) to predict outcomes in children with heart failure (HF) has not been well demonstrated. This study was designed to determineExpand
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RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy
Hypertrophic Cardiomyopathy (HCM) is a disease with variable rate of progression. Young age is an independent risk factor for poor outcome in HCM. The influence of renin–angiotensin–aldosteroneExpand
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Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy.
BACKGROUND MicroRNAs (miRNAs) are short regulatory RNAs that control gene expression through interacting with the 3'UTR of target messenger RNAs. The purpose of this study was to determine ifExpand
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The Hemodynamic Response to Dexmedetomidine Loading Dose in Children With and Without Pulmonary Hypertension
BACKGROUND:Dexmedetomidine, an &agr;-2 receptor agonist, is widely used in children with cardiac disease. Significant hemodynamic responses, including systemic and pulmonary vasoconstriction, haveExpand
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