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New Calcium Indicators and Buffers with High Selectivity against Magnesium and Protons : Design , Synthesis , and Properties of Prototype Structures ?
A new family of high-affinity buffers and optical indicators for Ca2+ is rationally designed and synthesized. The parent compound is 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA),Expand
The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils
24 di-, tri-, and tetrapeptides have been synthesized as a start of a systematic study of the structural requirements for chemotactic activity and lysosomal enzyme-releasing ability in rabbitExpand
Demonstration of a receptor on rabbit neutrophils for chemotactic peptides.
Abstract [3H]formylNorleu-Leu-Phe, a potent leucocyte chemoattractant, binds specifically to a site on rabbit neutrophils with an affinity of 1.5 × 10−9 M. Other acylated peptide chemoattractantsExpand
Role of a peptidase in phagocyte chemotaxis.
The potencies of N-formylmethionyl (fMet) peptides as chemotactic agents for phagocytes are related to the rates at which they are hydrolyzed. Furthermore, chloromethyl ketones inhibit chemotaxis asExpand
Antibiotics and peptides with agonist and antagonist chemotactic activity.
Abstract It has been found that the polypeptide antibiotics gramicidin S, tyrocidin and bacitracin, containing Leu-Phe or Ile-Phe sequences, are chemoattractants for neutrophils. Related syntheticExpand
Rapid Stimulation of protein carboxymethylation in leukocytes by a chemotactic peptide
THERE has been considerable interest recently in protein carboxylmethyltransferase, and in its possible role in secretory1 and chemotactic mechanisms2,3. Using S-adenosyl-L-methionine as the methylExpand
Synthesis and binding characteristics of an intrinsically radiolabeled chemotactic acyl tripeptide Nα‐Formyl—norleucyl—leucyl—phenylalanine
A large number of structurally unrelated compounds are known to be chemotactic to neutrophils [ 11. The heterogeneity of these molecules as well as the lack of structural information on many of themExpand
Some characteristics of the neutrophil receptor for chemotactic peptides
Formylated peptides have been shown to be potent chemoattractants for leukocytes [ 1,2]. With the aid of an intrinsically labelled chemoattractant, f-Nle-Leu-[‘HIPhe (ML[3H]P) [3], a high affinityExpand
Histamine release by chemotactic, formyl methionine-containing peptides.
Certain formyl dipeptides and tripeptides containing methionine released histamine from human basophils at concentrations of 10(-4) to 10(-7) M. However, N-formyl amino acids did not releaseExpand