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Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan‐glycocalyx
Liver sinusoidal endothelial cells (SECs) possess unique receptors that recognize and internalize hyaluronic acid (HA). To develop a system for targeting foreign DNA to SECs, comb‐type polycationsExpand
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Protective effects of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates against hepatic ischemia/reperfusion injury in vivo.
The complex between manganese (Mn) porphyrins and catalase-poly(ethylene glycol) (PEG) conjugates has been designed for the protective effect against hepatic ischemia/reperfusion injury in vivo. TheExpand
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Superoxide dismutase as a target enzyme for Fe-porphyrin-induced cell death.
The cell viability of human cancer cell lines treated with [5,10-bis(N-methyl-4-pyridyl)-15,20-diphenyl]porphinatoiron(III) (cis-FeMPy(2)P(2)P) has been estimated. The cis-FeMPy(2)P(2)P is aExpand
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Aminated poly(L-histidine) as new pH-sensitive DNA carrier.
The endosomal escape of the polyion complex between DNA and polycation is one of important factors for efficient gene expression. Here we have examined whether the poly(L-histidine) with severalExpand
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Synthesis of alkylated poly(1-vinylimidazole) for a new pH-sensitive DNA carrier.
The poly(1-vinylimidazole) (PVIm) with sever al alkyl groups has been synthesized as a new pH-sensitive DNA carrier. The resulting alkylaed PVIm (PVIm-R) was water -soluble in spite of theExpand
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Byproduct-Free Intact Modification of Insulin by Cholesterol End-Modified Poly(ethylene glycol) for in Vivo Protein Delivery.
Insulin is a key peptide hormone used for the treatment of both type I and type II diabetes. To maximize the effect of the treatment of these diseases, the addition of poly(ethylene glycol)Expand
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Up-regulation of gene expression by transfection to hepatocyte spheroids.
The gene expression is up-regulated by transfection to spheroids rather than monolayered cells. Monolayered hepatocytes form spheroids on rubbed polyimide membrane after 3 day incubation. TheExpand
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Design of manganese porphyrin modified with mitochondrial signal peptide for a new antioxidant.
A new design of antioxidant, consisting of manganese (Mn) porphyrin and signal peptide for mitochondrial targeting, is reported. The resulting Mn-porphyrin-oligopeptide conjugate exhibitedExpand
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Design of metalloporphyrin-carbohydrate conjugates for a new superoxide dismutase mimic with cellular recognition.
Metalloporphyrin-carbohydrate conjugates have been synthesized as superoxide dismutase (SOD) mimics with cellular recognition. To synthesize the conjugates, aliphatic primary amino groups forExpand
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Synthesis and characterization of alkylated poly(1-vinylimidazole) to control the stability of its DNA polyion complexes for gene delivery.
Poly(1-vinylimidazole) (PVIm) with alkylated imidazole groups has been synthesized as a pH-sensitive polycation to control the stability of its DNA polyion complexes for gene delivery. The resultingExpand
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