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Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
A large-scale genome-wide association study in a Japanese population provides insights into the etiology of complex diseases and highlights the importance of performing GWAS in non-European populations. Expand
Hippocampal degeneration inducing impairment of learning in rats: model of dementia?
- K. Ishikawa, T. Kubo, S. Shibanoki, A. Matsumoto, Hideyo Hata, S. Asai
- Medicine, Psychology
- Behavioural Brain Research
- 1 February 1997
The findings indicate that sole degeneration of the hippocampus was able to induce different types of memory impairment, and single evaluation of a drug with one learning paradigm was difficult to justify that a drug is effective for dementia. Expand
Haplotype Analysis of the Human Renin Gene and Essential Hypertension
The data suggest that the missense mutation in exon 9 may affect the enzymatic function of renin and consequently may be involved in the etiology of hypertension. Expand
Effects of brain temperature on CBF thresholds for extracellular glutamate release and reuptake in the striatum in a rat model of graded global ischemia
WE simultaneously measured extracellular glutamate ([Glu]e) elevation and local CBF using a real-time monitoring method and laser-Doppler flowmetry, respectively, in the rat striatum in a modified… Expand
Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia.
- Yayoi Nishida, T. Nagata, Yasuo Takahashi, Megumi Sugahara-Kobayashi, A. Murata, S. Asai
- Biology, Medicine
- Brain research. Molecular brain research
- 7 April 2004
In insight into the alterations of sgk-1 gene expression in the rat hippocampus after transient global cerebral ischemia, the increased level of sGk- 1 gene expression was found to localize in pyramidal cells of CA2 and CA3 regions of the hippocampus after 2 h of reperfusion. Expand
Overview of the BioBank Japan Project: Study design and profile
This report describes the study design and profile of BBJ participants who were registered during the first 5-year period of the project, and concludes that the BBJ Project has constructed the infrastructure for genomic research for various common diseases. Expand
Thymidylate synthase expression correlates closely with E2F1 expression in colon cancer.
- M. Kasahara, Y. Takahashi, +5 authors K. Ishikawa
- Biology, Medicine
- Clinical cancer research : an official journal of…
- 1 July 2000
Thymidylate synthase (TS) is thought to be one of the target genes that the E2F1 transcription factor binds to and regulates. However, the relationship between the expressions of TS and E2F1 in… Expand
Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array.
- T. Nagata, Yasuo Takahashi, +9 authors H. Mugishima
- Biology, Medicine
- International journal of molecular medicine
- 1 June 2003
Evidence of a differential expression profile of genes regulating the cell cycle, DNA replication and repair, cell growth, regulation of hormonal signals, and cellular metabolism, between FL and PNL in humans is provided. Expand
Affinity and kinetic analysis of the molecular interaction of ICAM-1 and leukocyte function-associated antigen-1.
Results suggest that the monovalent interaction between ICAM-1 and LFA-1 has a primarily high affinity and a slow dissociation rate constant as compared with other adhesion molecules, suggesting a potential mechanism for firm adhesion. Expand
Genotype and Haplotype Association Study of the STRK1 Region on 5q12 Among Japanese: A Case-Control Study
The aims of this haplotype-based case-control study were to confirm, using microsatellite markers and single-nucleotide polymorphisms (SNPs), whether PDE4D is also a susceptibility gene for cerebral infarction in Japanese subjects and to reveal that in addition to the region of the PDE 4D gene, another region existed within the STRK1 locus. Expand