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- S. Artavanis-Tsakonas, Matthew D Rand, Robert J. Lake
- Science
- 1999
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch… (More)
- Angeliki Louvi, S. Artavanis-Tsakonas
- Nature Reviews Neuroscience
- 2006
Signals through the Notch receptors are used throughout development to control cellular fate choices. Loss- and gain-of-function studies revealed both the pleiotropic action of the Notch signalling… (More)
- Richard G Fehon, I A Dawson, S. Artavanis-Tsakonas
- Development
- 1994
Protein 4.1 functions to link transmembrane proteins with the underlying spectrin/actin cytoskeleton. To permit a genetic analysis of the developmental role and cellular functions of this… (More)
- S. Artavanis-Tsakonas, Kenji Matsuno, Mark E. Fortini
- Science
- 1995
The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans. Studies on the expression, mutant phenotypes, and… (More)
- Mark E. Fortini, S. Artavanis-Tsakonas
- Cell
- 1994
In a genetic screen for mutations that attenuate Notch signaling in the developing Drosophila eye, we isolated rare, gain-of-function alleles of Suppressor of Hairless (Su(H)), the fly homolog of the… (More)
- Jeffrey D. Axelrod, Kenji Matsuno, S. Artavanis-Tsakonas, Norbert Perrimon
- Science
- 1996
In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events. Genetic analysis demonstrates that the dishevelled gene, which encodes a… (More)
- K. G. Guruharsha, Mark W. Kankel, S. Artavanis-Tsakonas
- Nature Reviews Genetics
- 2012
Notch signalling links the fate of one cell to that of an immediate neighbour and consequently controls differentiation, proliferation and apoptotic events in multiple metazoan tissues. Perturbations… (More)
- Ilaria Rebay, Richard G Fehon, S. Artavanis-Tsakonas
- Cell
- 1993
The Notch gene of Drosophila plays an important role in cell fate specification throughout development. To investigate the functions of specific structural domains of the Notch protein in vivo, a… (More)
- Nenad Sestan, S. Artavanis-Tsakonas, Pasko Rakić
- Science
- 1999
The exuberant growth of neurites during development becomes markedly reduced as cortical neurons mature. In vitro studies of neurons from mouse cerebral cortex revealed that contact-mediated Notch… (More)
- Edward L. Huttlin, Lily Ting, +26 authors Steven P Gygi
- Cell
- 2015
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we… (More)