Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages
- C. Klose, Melanie Flach, A. Diefenbach
- BiologyCell
- 10 April 2014
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
- S. Arnold, E. Robertson
- BiologyNature reviews. Molecular cell biology
- 1 February 2009
Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning in the early mammalian embryo.
The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.
- S. Arnold, Guo Huang, M. Groszer
- BiologyGenes & Development
- 15 September 2008
It is demonstrated that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits and is established as a key regulator of neurogenesis in the SVZ.
Pluripotency factors regulate definitive endoderm specification through eomesodermin.
- A. Teo, S. Arnold, L. Vallier
- BiologyGenes & Development
- 1 February 2011
Together, these results provide for the first time a comprehensive molecular model connecting the transition from pluripotency to endoderm specification during mammalian development.
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
- B. Hartleben, Markus Gödel, T. Huber
- Biology, MedicineJournal of Clinical Investigation
- 1 April 2010
It is postulate that constitutive and induced autophagy is a major protective mechanism against podocyte aging and glomerular injury, representing a putative target to ameliorate human glomersular disease and aging-related loss of renal function.
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation.
- S. Orsulic, O. Huber, H. Aberle, S. Arnold, R. Kemler
- BiologyJournal of Cell Science
- 15 April 1999
Using recombinant proteins, it is found that E-cadherin and lymphocyte-enhancer factor-1 (LEF-1) form mutually exclusive complexes with beta-catenin; the association of beta-Catenin with LEf-1 was competed out by the E- cadher in cytoplasmic domain.
Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
- S. Arnold, U. Hofmann, E. Bikoff, E. Robertson
- BiologyDevelopment
- 1 February 2008
It is established that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse.
The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
- Ita Costello, Inga-Marie Pimeisl, Sarah Dräger, E. Bikoff, E. Robertson, S. Arnold
- BiologyNature Cell Biology
- 7 August 2011
It is reported that Eomes expression within the primitive streak marks the earliest cardiac mesoderm and promotes formation of cardiovascular progenitors by directly activating the bHLH (basic-helix-loop-helIX) transcription factor gene Mesp1 upstream of the core cardiac transcriptional machinery.
Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.
- S. Arnold, Silvia Maretto, A. Islam, E. Bikoff, E. Robertson
- BiologyDevelopmental Biology
- 1 August 2006
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