Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning in the early mammalian embryo.
The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.
It is demonstrated that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits and is established as a key regulator of neurogenesis in the SVZ.
Pluripotency factors regulate definitive endoderm specification through eomesodermin.
Together, these results provide for the first time a comprehensive molecular model connecting the transition from pluripotency to endoderm specification during mammalian development.
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
It is postulate that constitutive and induced autophagy is a major protective mechanism against podocyte aging and glomerular injury, representing a putative target to ameliorate human glomersular disease and aging-related loss of renal function.
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation.
Using recombinant proteins, it is found that E-cadherin and lymphocyte-enhancer factor-1 (LEF-1) form mutually exclusive complexes with beta-catenin; the association of beta-Catenin with LEf-1 was competed out by the E- cadher in cytoplasmic domain.
Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
It is established that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse.
The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
- Ita Costello, Inga-Marie Pimeisl, Sarah Dräger, E. Bikoff, E. Robertson, S. Arnold
- BiologyNature Cell Biology
- 7 August 2011
It is reported that Eomes expression within the primitive streak marks the earliest cardiac mesoderm and promotes formation of cardiovascular progenitors by directly activating the bHLH (basic-helix-loop-helIX) transcription factor gene Mesp1 upstream of the core cardiac transcriptional machinery.
Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.