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LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement
TLDR
The main issue regarding testing is to restrict it to those who are known to be at higher risk of developing tuberculosis and who are willing to accept preventive chemotherapy, and to identify an adaptive immune response against, but not necessarily a latent infection with, M. tuberculosis.
Comparison of two interferon-gamma assays and tuberculin skin test for tracing tuberculosis contacts.
TLDR
Blood test results were associated with exposure, whereas the TST was not, and a possible lack of sensitivity of IFN-gamma assays in detecting individuals with TST of 15 mm or greater, despite negative bacillus Calmette-Guérin vaccination status, warrants further investigation into alternative cutoff values.
The risk of tuberculosis in transplant candidates and recipients: a TBNET consensus statement
TLDR
This management guideline summarises current knowledge on the prevention, diagnosis and treatment of TB related to solid organ and hematopoietic stem cell transplantation and provides an expert consensus on questions where scientific evidence is still lacking.
Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts
The authors determined the positive predictive value (PPV) for progression to tuberculosis (TB) of two interferon-γ release assays (IGRAs), QuantiFERON-TB® Gold In-tube (QFT-GIT) and T-SPOT.TB®, and
Antigenic Equivalence of Human T-Cell Responses toMycobacterium tuberculosis-Specific RD1-Encoded Protein Antigens ESAT-6 and Culture Filtrate Protein 10 and to Mixtures of Synthetic Peptides
TLDR
Results show that mixtures of synthetic overlapping peptide mixtures have potency equivalent to that of whole ESAT-6 and CFP-10 for sensitive and specific detection of infection with M. tuberculosis, and peptides have the advantage of faster production at lower cost.
Discrepancy between Mycobacterium tuberculosis-Specific Gamma Interferon Release Assays Using Short and Prolonged In Vitro Incubation
TLDR
Whether TST-positive persons with positive LST results but negative QFT-GIT and ELISPOT results are at risk for the development of TB needs to be elucidated before short-incubation IGRAs can be used for the screening of individuals for latent TB before immunosuppressive treatment.
Epitope Mapping of the Immunodominant Antigen TB10.4 and the Two Homologous Proteins TB10.3 and TB12.9, Which Constitute a Subfamily of the esat-6 Gene Family
TLDR
The fine specificity of the T-cell response to the three closely related esat-6 family members was markedly different, with only a few epitopes shared between the molecules, and the peptides from TB10.4 stimulated the largest responses, but epitopes unique to both TB 10.3 and TB12.9 were found.
PPE Protein (Rv3873) from DNA Segment RD1 of Mycobacterium tuberculosis: Strong Recognition of Both Specific T-Cell Epitopes and Epitopes Conserved within the PPE Family
TLDR
The immunodominant epitope for both TB patients and BCG-vaccinated individuals was found to be highly conserved among a large number of PPE family members, and the native protein, Rv3873, is predominantly associated with the mycobacterial cell or wall.
Nontuberculous mycobacterial infection in children: a 2-year prospective surveillance study in the Netherlands.
TLDR
The treatment of localized NTM infection in immunocompetent children by antimycobacterial drugs should be evaluated further.
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