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A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling
TLDR
This work provides genetic evidence in the mouse that precocious ETS expression in DRG sensory neurons perturbs axonal projections, the acquisition of terminal differentiation markers, and their dependence on neurotrophic support.
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
TLDR
A mechanism for the regulation of cofilin and hence of actin dynamics in vivo is defined and should play a central role in regulating cell motility and morphogenesis by modulating the stability of act in cytoskeletal structures.
Requirement for the Homeobox Gene Hb9 in the Consolidation of Motor Neuron Identity
TLDR
Findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs, and in mice lacking Hb9 function, MNs are generated on schedule and in normal numbers but transiently acquire molecular features of V2 interneurons.
Patterning of Muscle Acetylcholine Receptor Gene Expression in the Absence of Motor Innervation
TLDR
It is demonstrated that AChR expression is patterned in the absence of innervation, raising the possibility that similarly prepatterned muscle-derived cues restrict axon growth and initiate synapse formation.
Multiple origins of Cajal-Retzius cells at the borders of the developing pallium
TLDR
Using genetic tracing and ablation experiments in mice, it is shown that two subpopulations of Reelin+ Cajal-Retzius cells are generated from Dbx1-expressing progenitor domains of the developing pallium: the ventral pallium and the septum.
MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure
TLDR
In vivo analysis revealed that MLP-deficient mice reproduce the morphological and clinical picture of dilated cardiomyopathy and heart failure in humans, providing the first model for this condition in a genetically manipulatable organism.
A Role for Runx Transcription Factor Signaling in Dorsal Root Ganglion Sensory Neuron Diversification
TLDR
Genetic manipulations in the mouse embryo are used to examine how Runx transcription factor signaling controls the acquisition of distinct DRG neuronal subtype identities and suggest that Runx gene signaling plays a key role in sensory neuron diversification.
Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation
TLDR
The results establish MLP as an essential promoter of myogenesis and suggest that LIM-only proteins act via similar mechanisms to regulate aspects of cell differentiation.
Functionally Related Motor Neuron Pool and Muscle Sensory Afferent Subtypes Defined by Coordinate ETS Gene Expression
TLDR
It is shown that motor neuron pools and subsets of muscle sensory afferents can be defined by the expression of ETS genes, notably PEA3 and ER81, and that these genes may participate in the development of selective sensory-motor circuits in the spinal cord.
ETS Gene Er81 Controls the Formation of Functional Connections between Group Ia Sensory Afferents and Motor Neurons
TLDR
The Er81 mutant mice exhibit a severe motor discoordination, yet the specification of MNs and induction of muscle spindles occurs normally, and ER81 controls a late step in the establishment of functional sensory-motor circuitry in the developing spinal cord.
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