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The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans.
The results of this study show that the rIPC stimulus modifies leukocyte inflammatory gene expression, which may contribute to the protective effect of IPC against IR injury and may have broader implications in other inflammatory processes.
Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload
Genetic data show that the endogenous peptide Apelin is crucial to maintain cardiac contractility in pressure overload and aging.
Intracellular targeting of the endoplasmic reticulum/nuclear envelope by retrograde transport may determine cell hypersensitivity to verotoxin via globotriaosyl ceramide fatty acid isoform traffic
It is proposed that the isoform‐dependent traffic of Gb3 from the cell surface to the ER/nuclear membrane provides a new signal transduction pathway for Gb 3 binding proteins.
Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction
- B. Ayach, M. Yoshimitsu, Peter P. Liu
- Biology, MedicineProceedings of the National Academy of Sciences…
- 7 February 2006
A previously uncharacterized role for c-kit signaling after infarction is revealed by mediating bone marrow-derived NK and angiogenic cell mobilization, which contributes to improved remodeling and cardiac function after MI.
Gelsolin Regulates Cardiac Remodeling After Myocardial Infarction Through DNase I–Mediated Apoptosis
It is found that GSN−/− mice have a surprisingly lower mortality, markedly reduced hypertrophy, smaller late infarct size, less interstitial fibrosis, and improved cardiac function when compared with GSN+/+ mice.
Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery.
Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function.
ILK serves to link mechanoreception to the dynamic modulation of cardiac contractility through a previously undiscovered interaction with the functional SERCA-2a/PLN module that can be exploited to rescue impaired mechanotransduction in DCM.
Day/night rhythms in gene expression of the normal murine heart
Gene expression in the heart is remarkably different in the day versus the night, and some gene cycling may be driven by the central circadian pacemaker, while other changes appear to be responses to light and dark.
Comparative Proteomics Profiling of a Phospholamban Mutant Mouse Model of Dilated Cardiomyopathy Reveals Progressive Intracellular Stress Responses*S
The results offer a systems-wide perspective of the dynamic maladaptions associated with impaired Ca2+ homeostasis that perturb myocyte function and ultimately converge to cause HF.
Verotoxin induces apoptosis and the complete, rapid, long-term elimination of human astrocytoma xenografts in nude mice.
To address whether this represents a feasible approach to the elimination of these tumors in man, human astrocytoma tumor xenografts in nude mice were treated with verotoxin and complete regression of a 1-cm-diameter tumor within 10 days was observed in all treated animals.