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Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.
The duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin is described, which may be an attractive new agent for the chemosensitization of cancer cells. Expand
Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.
Curcumin I is the most effective MDR modulator among curcuminoids, and may be used in combination with conventional chemotherapeutic drugs to reverse MDR in cancer cells. Expand
Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy
The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy.Expand
Investigation of fruit peel extracts as sources for compounds with antioxidant and antiproliferative activities against human cell lines.
It is concluded that the ethyl acetate fraction of rambutan peel is a promising resource for potential novel antioxidant agents whereas the hexane fraction of coconut peel may contain novel anticancer compounds. Expand
Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids
It is indicated that bisdemethoxycurcumin is the most active of the curcuminoids present in turmeric for modulation of MDR-1 gene, which may be an attractive target for new chemosensitizing agents. Expand
Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines
PureCurcumin, an excellent curcuminoid derivative, decreased WT1 gene expression in both transcriptional and translational levels and is one of a potential chemotherapeutic agent used for treatment of human leukemia. Expand
Inhibitory effect of curcumin onMDR1 gene expression in patient leukemic cells
Curcumin treatment may provide a lead for clinical treatment of leukemia patients in the future after it was found that curcumin reduced MDR1 gene expression in the cells from 33 patients. Expand
CXCR4 targeted dendrimer for anti‐cancer drug delivery and breast cancer cell migration inhibition
The potential utility of LFC131‐dendrimer conjugates for breast cancer therapy and metastasis is demonstrated, with significantly enhanced in vitro cellular toxicity as compared with non‐targeted dendrimers. Expand
The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells
Results suggest that Cur, DMC, and BDMC may be used as M MP-3 inhibitors to modulate MMP-3 expression and inhibit cell invasion and motility. Expand
Anti-P-glycoprotein conjugated nanoparticles for targeting drug delivery in cancer treatment
The results had confirmed the specificity and the potential of the developed targeted delivery system for overcoming multi-drug resistance induced by overexpression of P-gp on the cell membrane. Expand