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A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity.
The molecular chaperones have been implicated in numerous neurodegenerative disorders in which the defining pathology is misfolded proteins and the accumulation of protein aggregates. In Alzheimer'sExpand
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Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.
Alzheimer's disease (AD) neuropathology is characterized by loss of synapses and neurons, neuritic plaques consisting of beta-amyloid (Abeta) peptides, and neurofibrillary tangles consisting ofExpand
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TCP-FA4: a derivative of tranylcypromine showing improved blood-brain permeability.
A variety of approaches have been taken to improve the brain penetration of pharmaceutical agents. The amphipathic character of a compound can improve its interaction with the lipid bilayer withinExpand
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beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton.
In vitro studies designed to probe the cellular mechanisms underlying beta-amyloid (Abeta) toxicity in neurons have implicated several processes, including hyperphosphorylation of the microtubuleExpand
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β-Amyloid-Induced Neurodegeneration and Protection by Structurally Diverse Microtubule-Stabilizing Agents
Deposition of β-amyloid peptide (Aβ) and hyperphosphorylation of the τ protein are associated with neuronal dysfunction and cell death in Alzheimer's disease. Although the relationship between theseExpand
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Therapeutic role of quercetin on oxidative damage induced by acrylamide in rat brain
Abstract Context Quercetin (QE), a bioflavonoid present abundantly in fruits and vegetables, has been reported to possess antioxidant properties. Acrylamide (ACR) is formed in foods during cookingExpand
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Cytoskeletal integrity as a drug target.
The cytoskeleton provides structural integrity and determines localization of proteins and organelles throughout the cell. The focus on structure and transport has overshadowed the role thisExpand
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(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent.
Compounds that interact with microtubules, such as paclitaxel, have been shown to possess protective properties against beta-amyloid (Abeta) induced neurodegeneration associated with Alzheimer'sExpand
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p35/Cyclin-dependent kinase 5 is required for protection against β-amyloid-induced cell death but not tau phosphorylation by ceramide
Ceramide is a bioactive sphingolipid, that can prevent calpain activation and β-amyloid (Aß) neurotoxicity in cortical neurons. Recent evidence supports Aß induction of a calpain-dependent cleavageExpand
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Effect of rutin on proinflammatory cytokines and oxidative stress in toxin-mediated hepatotoxicity
Abstract The present study was designed to evaluate the effect of rutin (RT) on lead (Pb)-induced oxidative stress. Rats were divided into groups and were treated with RT with or without lead. LevelsExpand
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