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Pharmacokinetics of flupirtine in elderly volunteers and in patients with moderate renal impairment.
TLDR
It would be prudent to start treatment of patients who are elderly or have evidence of renal impairment with half the dose of flupirtine recommended for younger patients with normal renal function.
Trazodone--a new assay procedure and some pharmacokinetic parameters.
TLDR
The peak plasma concentration, time to peak concentration, area under the curve, elimination rate constant and half-life were determined and the two formulations of trazodone were considered to have comparable bioavailability.
Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly.
TLDR
The elderly subjects were less alert for a longer period following drug administration than the young and the differing pharmacokinetic and pharmacodynamic characteristics of trazodone in the young may be due to an age-related reduction in hepatic drug-metabolic activity, a difference in regional distribution or a change in CNS sensitivity to the drug.
Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly.
TLDR
The results are compatible with previous evidence of increased 'sensitivity' to benzodiazepines in the elderly and suggest that a lower starting dose of loprazolam would be appropriate for older recipients.
A double‐blind placebo‐controlled study of the efficacy and tolerability of ebastine against hayfever in general practice patients
TLDR
A double‐blind placebo‐controlled study of the efficacy and tolerability of ebastine against hayfever in general practice patients is presented.
Evaluation of possible interactions between ethanol and trazodone or amitriptyline.
TLDR
Ethanol alone impaired manual dexterity, increased drowsiness, reduced 'clearheadedness' and also tended to reduce feelings of aggression and in combination with either trazodone or amitriptyline, ethanol caused little additional effect, which may reflect the profound effects of the antidepressants alone.
Pharmacokinetics and pharmacodynamics following single and repeated nightly administrations of loprazolam, a new benzodiazepine hypnotic.
TLDR
After repeated doses of loprazolam, there were no significant changes with respect to results after single doses in psychomotor function assessed objectively by critical flicker fusion threshold or choice reaction time, or in sleep quality or behaviour on awakening assessed subjectively by 10 cm analogue scales.
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