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A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons.
- C. Fode, Q. Ma, S. Casarosa, S. Ang, D. Anderson, F. Guillemot
- BiologyGenes & development
- 1 January 2000
The results indicate that in addition to acting as neuronal determinants, Mash1 and Ngns play a role in the specification of dorsal-ventral neuronal identity, directly linking pathways of neurogenesis and regional patterning in the forebrain.
HNF-3 beta is essential for node and notochord formation in mouse development.
The primary defect of HNF-3 beta -/- embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube, and patterning along the anterior-posterior axis was surprisingly little affected.
HNF-3β is essential for node and notochord formation in mouse development
The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins.
The discovery that the rat hepatocyte transcription factor HNF3 is similar to the Drosophila forkhead gene, which plays a critical role in gut development in the fly, led us to isolate genes containing the H NF3/forkhead (HFH) domain that are expressed in mouse endoderm development and discover a novel HFH-containing gene.
Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants.
Using explant-recombination assays, evidence is obtained that a positive signal from anterior mesendoderm is required to stabilize expression of Otx2 in vivo, whereas a negative signal from the later-forming posterior mesENDoderm represses Otx1 expression in the posterior part of the embryo.
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.
- M. Ishibashi, S. Ang, K. Shiota, S. Nakanishi, R. Kageyama, F. Guillemot
- BiologyGenes & development
- 15 December 1995
Results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis.
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner
It is demonstrated that Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner and Interestingly, genetic evidence indicates that these functions require different gene dosages of Foxa 1 and FoxA2.
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.
It is demonstrated that Otx2 is required for proper development of the epiblast and patterning of the anterior brain in mice, and the idea of evolutionary conservation of the function of Otd/Otx genes in head development in flies and mice is supported.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling
It is shown that in zebrafish, Sef functions as a feedback-induced antagonist of Ras/Raf/MEK/MAPK-mediated FGF signalling.