CHARACTERIZATION AND PARTIAL PURIFICATION OF THE RAT AND HUMAN ENZYME SYSTEMS ACTIVE IN THE REDUCTION OF N-HYDROXYMELAGATRAN AND BENZAMIDOXIME
- S. Andersson, Y. Hofmann, I. Johansson
- Biology, ChemistryDrug Metabolism And Disposition
- 1 April 2005
The unique appearance of the enzyme activity in adipose tissue, together with the cyanide sensitivity and the failure of typical P450 inhibitors to impede the reaction, indicates that the enzyme system active in reduction of benzamidoxime and N-hydroxymelagatran formation is not of cytochrome P450 origin, but likely consists of an NADH-dependent electron transfer chain with a cyanide-sensitive protein as the terminal component.
The enzymatic synthesis of membrane glucolipids in Acholeplasma laidlawii.
- A. Dahlqvist, S. Andersson, A. Wieslander
- Biology, ChemistryBiochimica et Biophysica Acta
- 23 March 1992
High-Precision, Room Temperature Screening Assay for Inhibitors of Microsomal Prostaglandin E Synthase-1
- S. Andersson, Mattias Norman, Rolf Olsson, Robin Smith, Gang Liu, J. Nord
- Chemistry, BiologyJournal of biomolecular screening
- 1 December 2012
A robust and practical automated assay in a 384-well format for room temperature screening of mPGES-1 inhibitors with high precision and low reagent consumption and should enable precise structure-activity relationship development is reported.