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Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*
Findings suggest that AID is a new member of the RNA-editing deaminase family and may play a role in genetic events in the germinal center B cell.
Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe
The data demonstrate that the RNA stabilizing and translation regulatory protein RBM3 is a novel proto-oncogene that induces transformation when overexpressed and is essential for cells to progress through mitosis.
DNA Methyltransferases: A Novel Target for Prevention and Therapy
Inhibition of DNMTs has demonstrated reduction in tumor formation in part through the increased expression of tumor suppressor genes, and this represents a promising approach for the prevention and treatment of many cancers.
Identification of a Novel Putative Gastrointestinal Stem Cell and Adenoma Stem Cell Marker, Doublecortin and CaM Kinase‐Like‐1, Following Radiation Injury and in Adenomatous Polyposis Coli/Multiple…
Targeting DCAMKL‐1 may represent a strategy for developing novel chemotherapeutic agents for treating gut stem cells with radiation‐induced stem cell apoptosis and adenomatous polyposis coli/multiple intestinal neoplasia mice to determine the effects of APC mutation.
Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.
DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.
Increased expression of the putative pancreatic stem cell marker DCAMKL-1 is reported in an established KRAS transgenic mouse model of pancreatic cancer and in human pancreatic adenocarcinoma, and a functional role is demonstrated for DCAMC-1 in Pancreatic cancer.
Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo.
The results show the involvement of Msi-1 in cancer cell proliferation, inhibition of apoptosis, and mitotic catastrophe, suggesting an important potential mechanism for its role in tumorigenesis.
Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating akt and p38 mAPK
Results showed that curcumin inhibits the proliferation of cisplatin-resistant ovarian cancer cells through the induction of superoxide generation, G2/M arrest, and apoptosis.
Diphenyl difluoroketone: a curcumin derivative with potent in vivo anticancer activity.
The data suggest that the novel curcumin-related compound EF24 is a potent antitumor agent that induces caspase-mediated apoptosis during mitosis and has significant therapeutic potential for gastrointestinal cancers.
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
This review summary of the research being carried out using different species of nanoparticles for enhanced radiosensitization in cancer concludes that nanoparticles have played a key role in the enhancement of the radiation therapy.