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Pharmacokinetic and imaging studies in patients receiving a formulation of liposome-associated adriamycin.
Pharmacokinetic and imaging studies in 19 patients receiving liposome-entrapped adriamycin (L-ADM) were carried out within the framework of a Phase I clinical trial (Gabizon et al., 1989a). TheExpand
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Systemic administration of doxorubicin-containing liposomes in cancer patients: a phase I study.
A clinical study was designed to evaluate the tolerance of cancer patients to liposome-associated doxorubicin (L-DXR). The liposomes used contain phosphatidylglycerol, phosphatidylcholine,Expand
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Optimization and upscaling of doxorubicin-containing liposomes for clinical use.
This work describes the optimization of a doxorubicin (DXR)-containing liposome formulation and its upscaling for human therapy. Multilamellar vesicles (MLV) composed of egg phosphatidylcholine,Expand
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Efficient treatment of murine systemic infection with Candida albicans using amphotericin B incorporated in nanosize range particles (emulsomes)
Summary. The effects of emulsome nanosize range lipid particles containing amphotericin B (EAmB) were compared with the reference formulation containing deoxycholate (Fungizone; Bristol‐Myers Squibb,Expand
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Liposomes containing lipid A as a potent non-toxic adjuvant.
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Polyanhydrides: Synthesis and characterization
The delivery of drugs from biodegradable polymeric materials for human and animal use has attracted considerable attention of investigators throughout the scientific community. Various types ofExpand
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Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220.
The aim of this article was to investigate the role of intestinal lymphatic transport in the oral bioavailability of two structurally similar synthetic lipophilic cannabinoids: dexanabinol andExpand
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In vitro tests to predict in vivo performance of liposomal dosage forms.
Design of liposome-based formulations for clinical use can be assisted by employing in vitro assays to predict pharmacokinetics and bioavailability of the drug before employing costly andExpand
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Disseminated visceral fusariosis treated with amphotericin B-phospholipid complex.
Fusariosis, a rare infectious disease of the immunocompromised host, is relatively resistant to amphotericin B (AmB) or other antifungal agents. We describe a 5-year follow-up of a 40 year old womanExpand
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Degradable polymers for site-specific drug delivery
The present article was aimed to review the properties and applications of the actually available biodegradable polymers that have been used as targetable drug carriers and site-specific deliveryExpand
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