The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
- S. Altman
- BiologyRNA: A publication of the RNA Society
- 1 April 2015
In molecular biology the discovery of DNA sequences that are into not proteins is a step towards solving the mystery of why DNA sequences are made into proteins.
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
Here, we discuss three RNA-based therapeutic technologies exploiting various oligonucleotides that bind to RNA by base pairing in a sequence-specific manner yet have different mechanisms of action…
Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.
The catalytic RNA subunit (M1 RNA) of RNase P from Escherichia coli has been converted to an endoribonuclease that specifically cleaves the mRNA that encodes thymidine kinase (TK) of herpes simplex…
Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae.
Depletion of RPP1 in vivo leads to the accumulation of precursor tRNAs with unprocessed 5' and 3' termini and reveals rRNA processing defects that have not been described previously for proteins associated with RNase P or RNase MRP.
Kinetics of the processing of the precursor to 4.5 S RNA, a naturally occurring substrate for RNase P from Escherichia coli.
Similar cage-shaped structures for the RNA components of all ribonuclease P and ribonuclease MRP enzymes
Structure and transcription of a human gene for H1 RNA, the RNA component of human RNase P
Southern hybridization analysis indicates that there is very likely only one copy of the gene for H1 RNA in the human genome.
Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.
- P. Eder, R. Kekuda, V. Štolc, S. Altman
- BiologyProceedings of the National Academy of Sciences…
- 18 February 1997
Peptide fragments derived from purified p30 and p38 facilitated the molecular cloning and sequencing of cDNAs coding for these two polypeptides, which are now designated as Rpp30 and Rpp38, respectively.
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
The two URLs in Methods are incorrect, and the correct URLs are given below.