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CK2 Forms a Stable Complex with TFIIIB and Activates RNA Polymerase III Transcription in Human Cells
TLDR
The data suggest that CK2 stimulates PolIII transcription by binding and phosphorylating TFIIIB and facilitating its recruitment by TFIIIC2, which may provide a mechanism to coregulate the output of PolI and PolIII. Expand
Retinoblastoma Protein Disrupts Interactions Required for RNA Polymerase III Transcription
TLDR
Evidence that histone deacetylases exert a negative effect on Pol III activity in vivo is presented, however, RB remains able to regulate Pol III transcription in the presence of the histoneDeacetylase inhibitor trichostatin A. Expand
SIRT3 is Pro-Apoptotic and Participates in Distinct Basal Apoptotic Pathways
TLDR
It is demonstrated that SIRT3 functions in JNK2-regulated apoptosis but is dispensable for SIRT1- regulated apoptosis, indicating the pro-apoptotic functioning of Sirt3 is selectively coupled with defined pathways regulating cell survival under basal conditions. Expand
JNK2-dependent regulation of SIRT1 protein stability
TLDR
It is shown that JNK2 is linked, directly or indirectly, with Sirt1 protein stability and that this function is coupled with SIRT1 phosphorylation at serine 27, which identifies a route for therapeutic modulation of SIRT 1 protein levels in SIRT2-linked diseases including cancer, neurodegeneration and diabetes. Expand
Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells
TLDR
Evidence is presented that SIRT1, an aging-related NAD-dependent deacetylase, mediates HPV E7 survival function in SiHa cervical cancer cells and this link may open the way for a more in-depth understanding of the process of HPV-induced malignant transformation and the inter-relationships between aging and cancer. Expand
Development and characterization of a microfluidic model of the tumour microenvironment
TLDR
The versatility of this microfluidic platform allows for different aspects of the microenvironment to be monitored and dissected and the device’s potential to enable more physiological in vitro drug screening is indicated. Expand
RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.
TLDR
The data suggest that overexpression of TFIIIC2 contributes to the abnormal abundance of pol III transcripts in ovarian tumors, and this factor may be fundamental because healthy cells use two key tumor suppressors to restrain pol III activity. Expand
RNA Polymerase III Transcription Factor IIIB Is a Target for Repression by Pocket Proteins p107 and p130
TLDR
It is concluded that TFIIIB is targeted for repression not only by RB but also by its relatives p107 and p130, which are two closely related proteins that display 30 to 35% identity with the RB polypeptide and share some of its functions. Expand
Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy.
TLDR
It is suggested that loss of p53, directly or indirectly, perturbs the normal regulation of S10 phosphorylation and may contribute toward the development of abnormal chromosomes and aneuploidy in p53-deficient cancers. Expand
SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53
TLDR
The first alternative isoform of SIRT1 is characterized, demonstrating its evolutionary conservation in mammalian tissues and revealing a new level of inter-dependency between p53 and Sirt1, two master regulators of multiple phenomena. Expand
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