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Large-Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology
TLDR
The majority of Bacilli natural products are comprised of a small set of highly conserved, well-distributed, known natural product compounds, most of these metabolites have important roles influencing the physiology and development of Bacillus species.
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Aerobic copper-catalyzed organic reactions.
TLDR
The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and CuIII oxidation states allowing it to act through one-electron or two-Electron processes, which feature confer a remarkably broad range of activities allowing copper to catalyze the oxidation and oxidative union of many substrates.
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Asymmetric Oxidative Coupling of Phenols and Hydroxycarbazoles
TLDR
Generation of a more vanadium catalyst by ligand design and by addition of an exogenous Brønsted or Lewis acid was found to be key to coupling the more oxidatively resistant phenols.
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Dynamic Docking of Conformationally Constrained Macrocycles: Methods and Applications.
TLDR
Methods for treating and docking the complicated binding modalities and flexible scaffolds of macrocyclic natural products and natural product-like structures are reviewed and some of the resulting advances in medicinal chemistry are discussed.
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Aerobic Copper‐Catalyzed Organic Reactions
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Production of Sactipeptides in Escherichia coli: Probing the Substrate Promiscuity of Subtilosin A Biosynthesis.
TLDR
It is shown that the positions of the sactionine linkages can be moved, giving rise to new, unnatural sactipeptide structures, demonstrating broad substrate promiscuity where none was previously known.
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Enantioselective Vanadium-Catalyzed Oxidative Coupling: Development and Mechanistic Insights.
TLDR
Experimental and quantum mechanical studies of the mechanism indicate that the additives aggregate the vanadium monomers, and a singlet to triplet crossover is implicated prior to carbon-carbon bond formation.
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Oxyanion steering and CH-π interactions as key elements in an N-heterocyclic carbene-catalyzed [4 + 2] cycloaddition.
TLDR
It is shown that a concerted, but highly asynchronous, Diels-Alder reaction occurs rather than the stepwise Michael-type or Claisen-type pathways and two crucial interactions are identified that enable high selectivity: an oxyanion-steering mechanism and a CH-π interaction.
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Concerted Amidation of Activated Esters: Reaction Path and Origins of Selectivity in the Kinetic Resolution of Cyclic Amines via N-Heterocyclic Carbenes and Hydroxamic Acid Cocatalyzed Acyl Transfer
TLDR
A quantum mechanical study of the reaction mechanism indicates that the selectivity-determining aminolysis step occurs via a novel concerted pathway in which the hydroxamic acid plays a key role in directing proton transfer from the incoming amine.
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Asymmetric hydrogenation of alpha-primary and secondary amino ketones: efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine.
Two beta-receptor agonists (-)-denopamine and (-)-arbutamine were prepared in good yields and enantioselectivities by asymmetric hydrogenation of unprotected amino ketones for the first time by using…
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