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Metabolic effects of a growth hormone-releasing factor in patients with HIV.
- J. Falutz, S. Allas, +9 authors S. Grinspoon
- The New England journal of medicine
- 6 December 2007
BACKGROUND Visceral adipose tissue accumulates during antiretroviral therapy in many patients who are infected with the human immunodeficiency virus (HIV); this process is associated with an… Expand
A placebo-controlled, dose-ranging study of a growth hormone releasing factor in HIV-infected patients with abdominal fat accumulation
Objective:To investigate the effects of TH9507, a novel growth hormone releasing factor, on abdominal fat accumulation, metabolic and safety parameters in HIV-infected patients with central fat… Expand
Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation
Objective:Treatment of HIV patients with daily tesamorelin, a growth hormone-releasing factor analogue, for 26 weeks resulted in a significant decrease in visceral adipose tissue (VAT) and… Expand
Safety, tolerability, pharmacokinetics and pharmacodynamics of AZP‐531, a first‐in‐class analogue of unacylated ghrelin, in healthy and overweight/obese subjects and subjects with type 2 diabetes
- S. Allas, T. Delale, +5 authors A. J. van der Lely
- Diabetes, obesity & metabolism
- 1 September 2016
To explore the safety, pharmacokinetics and pharmacodynamics in humans of the unacylated ghrelin analogue AZP‐531, designed to improve glycaemic control and reduce weight.
In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues.
- M. Julien, R. Kay, +7 authors T. Abribat
- Chemistry, Medicine
- European journal of pharmaceutical sciences…
- 20 November 2012
Ghrelin, an endocrine hormone predominantly produced by the stomach, exists in acylated and unacylated forms in the circulation. Unacylated ghrelin (UAG), the more abundant form in blood, possesses… Expand
Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines
Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) cell lymphoma. Although… Expand
Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader–Willi syndrome
Prader–Willi syndrome (PWS) is characterized by a switch from failure to thrive to excessive weight gain and hyperphagia in early childhood. Hyperghrelinemia may be involved in the underlying… Expand
Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase
SummaryBacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an indispensable component used in the treatment of acute lymphoblastic leukemia (ALL) and certain lymphoma entities.… Expand
Unacylated ghrelin analog prevents myocardial reperfusion injury independently of permeability transition pore
Reperfusion injury is responsible for an important part of myocardial infarct establishment due notably to triggering cardiomyocytes death at the first minutes of reperfusion. AZP-531 is an optimized… Expand
Healing mechanisms in experimental aneurysms. I. Vascular smooth muscle cells and neointima formation.
- J. Raymond, D. Venne, +5 authors G. Leclerc
- Journal of neuroradiology. Journal de…
- 1 March 1999
PURPOSE The purpose of this work is to better define healing phenomena in this model, in an effort to find strategies to improve long term results of endovascular treatment. METHODS Lateral wall… Expand