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Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity.
TLDR
The results demonstrate that DCF fluorescence provides a good measure of overall ROS formation in synaptosomes of both in vitro as well as in vivo systems, and support that oxidative damage may be the primary mechanism underlying the neurotoxicity induced by these organometals. Expand
Organometal-induced increases in oxygen reactive species: the potential of 2',7'-dichlorofluorescin diacetate as an index of neurotoxic damage.
TLDR
The data demonstrate that oxygen reactive species are elevated in brain regions, cerebellum (MeHg) and hippocampus, believed to be selectively vulnerable to these toxic agents, and suggest that oxidative damage may be a mechanism underlying the toxicity of both organometals. Expand
The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum.
TLDR
A cold environmental temperature (4 degrees C) reduced the effects of METH on striatal DA levels and striatal TH activity. Expand
Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate
TLDR
It is concluded that the acute effect of MDMA on caudate is at least as great on the DA as it is on the 5-HT system. Expand
Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles.
TLDR
The data suggest that Ag-25 nanoparticles may produce neurotoxicity by generating free radical-induced oxidative stress and by altering gene expression, producing apoptosis and neurotoxicity. Expand
Age-related changes in antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase and glutathione in different regions of mouse brain
TLDR
It is demonstrated that although the level of antioxidant enzymes varied in different regions of the brain, overall the enzyme activities tend to increase with age. Expand
The impact of gender and estrogen on striatal dopaminergic neurotoxicity.
TLDR
Estrogen replacement reduced the DA, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) depletions as well as the glial fibrillary acidic protein (GFAP) elevation induced by MPTP, which indicates that estrogen has neuroprotective properties in this model of striatal dopaminergic neurotoxicity. Expand
Acute effects of delta-9-tetrahydrocannabinol in rhesus monkeys as measured by performance in a battery of complex operant tests.
TLDR
It is indicated that THC, at doses that produce plasma levels similar to those noted in humans after marijuana smoke exposure, produce acute behavioral effects on temporal differentiation in monkeys analogous to some effects reported in humans. Expand
Influence of inducers and inhibitors on the metabolism in vitro and neurochemical effects in vivo of MDMA.
TLDR
The results suggest that the neurochemical effects of MDMA are caused by the formation of an active metabolite in vivo, and since both enantiomers were N-demethylated in vitro to approximately the same extent by PB pretreated rat liver microsomes, the active metabolites may be other than MDA. Expand
Behavioral and neurochemical effects of chronic methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys.
TLDR
It is suggested that chronic administration of gradually increasing doses of MDMA results in long-lasting tolerance to the drugs acute effects on the complex brain functions modeled in the OTB, uncertain, however, if such tolerance is related to the observed decreases in uptake sites and turnover of 5-HT in the hippocampus of these monkeys. Expand
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