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Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury
This study characterized the effects of diabetes and/or ischemia on epidermal growth factor receptor, EGFR, and/or erbB2 signaling pathways on cardiac function. Isolated heart perfusion model ofExpand
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Angiotensin‐(1‐7) inhibits epidermal growth factor receptor transactivation via a Mas receptor‐dependent pathway
BACKGROUND AND PURPOSE The transactivation of the epidermal growth factor (EGF) receptor appears to be an important central transduction mechanism in mediating diabetes‐induced vascular dysfunction.Expand
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Angiotensin‐(1–7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2‐ and NF‐κB‐dependent pathways
BACKGROUND AND PURPOSE Angiotensin‐(1–7) [Ang‐(1–7)] has anti‐inflammatory effects in models of cardiovascular disease and arthritis, but its effects in asthma are unknown. We investigated whetherExpand
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Characterization of Angiotensin-(1-7) effects on the cardiovascular system in an experimental model of type-1 diabetes.
Although exogenous administration of Angiotensin-(1-7) [Ang-(1-7)] can prevent development of diabetes induced end-organ damage, little is known about the role of endogenous Ang-(1-7) in diabetes andExpand
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Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradable polymer microspheres
Macrophages are important reservoirs of infection including the human immunodeficiency virus (HIV) virus and strategies which target therapeutic agents to these cells appear worthwhile. In thisExpand
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Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities.
The mechanisms by which angiotensin-(1-7) [Ang-(1-7)] exerts its beneficial effects on end-organ damage associated with diabetes and hypertension are not well understood. The purpose of this studyExpand
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Oral delivery of siRNA and antisense oligonucleotides
  • S. Akhtar
  • Medicine, Chemistry
  • Journal of drug targeting
  • 27 July 2009
Inhibition of gene expression with antisense oligonucleotides or RNA interference (RNAi) mediated gene silencing by small interfering RNA (siRNA) has tremendous potential to silence the expression ofExpand
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Phosphoinositide 3‐kinase mediated signalling contributes to development of diabetes‐induced abnormal vascular reactivity of rat carotid artery
Diabetes mellitus is associated with vascular complications, including an impairment of vascular function and alterations in the reactivity of blood vessels to vasoactive agents. PhosphatidylinositolExpand
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Endogenous angiotensin-(1-7)/Mas receptor/NO pathway mediates the cardioprotective effects of pacing postconditioning.
The aim of the present study was to investigate the role of the ANG-(1-7) receptor (Mas) and nitric oxide (NO) in pacing postconditiong (PPC)-mediated cardioprotection against ischemia-reperfusionExpand
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