S. Aimoto

Publications313
h-index45
Citations7,399
Highly Influential Citations204
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Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils
The amyloid-β1–42 (Aβ42) peptide rapidly aggregates to form oligomers, protofibils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. We show that… Expand
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Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
A novel murine cDNA which encodes a protein designated neuropsin was cloned. Northern and in situ hybridization analyses demonstrated that neuropsin mRNA is expressed specifically in the limbic… Expand
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Structure of the transmembrane dimer interface of glycophorin A in membrane bilayers.
The hydrophobic transmembrane domain of glycophorin A contains a sequence motif that mediates dimerization in membrane environments. Long-range interhelical distance measurements using magic angle… Expand
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Ribosome modulation factor: stationary growth phase-specific inhibitor of ribosome functions from Escherichia coli.
Ribosome modulation factor (RMF) is an Escherichia coli protein associated with 100S ribosome dimers, which are formed at stationary growth phase or in slowly growing cells. RMF either purified from… Expand
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Site‐Specific Phosphorylation of Neurofilament‐L Is Mediated by Calcium/Calmodulin‐Dependent Protein Kinase II in the Apical Dendrites During Long‐Term Potentiation
Abstract : Neurofilament‐L (NF‐L), one subunit of the neuronal intermediate filaments, is a major element of neuronal cytoskeletons. The dynamics of NF‐L are regulated by phosphorylation of its head… Expand
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Comparison of the free and DNA-complexed forms of the DMA-binding domain from c-Myb
The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif.… Expand
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Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core.
The DNA-binding domain of the c-myb protooncogene product consists of three imperfect tandem repeats of 51 or 52 amino acids, each of which contains three conserved tryptophans, spaced 18 or 19 amino… Expand
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Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.
Amyloid fibrils associated with Alzheimer's disease and a wide range of other neurodegenerative diseases have a cross beta-sheet structure, where main chain hydrogen bonding occurs between… Expand
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Hinge and chromoshadow of HP1α participate in recognition of K9 methylated histone H3 in nucleosomes.
The majority of the genome in eukaryotes is packaged into transcriptionally inactive chromatin. Heterochromatin protein 1 (HP1) is a major player in the establishment and maintenance of… Expand
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Transmembrane interactions in the activation of the Neu receptor tyrosine kinase.
The Neu receptor tyrosine kinase is constitutively activated by a single amino acid change in the transmembrane domain of the receptor. The mutation of Val664 to glutamate or glutamine induces… Expand
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