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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure ofExpand
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Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry
Numerous obesity loci have been identified using genome-wide association studies. A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replicationExpand
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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interactionExpand
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Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry
Abstract Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether aExpand
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Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study
BackgroundMultiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors inExpand
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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution toExpand
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The lysine specific demethylase‐1 (LSD1/KDM1A) regulates VEGF‐A expression in prostate cancer
Recurrent prostate cancer remains a major clinical challenge. The lysine specific demethylase‐1 (LSD1/KDM1A), together with the JmjC domain‐containing JMJD2A and JMJD2C proteins, have emerged asExpand
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Innate biology versus lifestyle behaviour in the aetiology of obesity and type 2 diabetes: the GLACIER Study
Aims/hypothesisWe compared the ability of genetic (established type 2 diabetes, fasting glucose, 2 h glucose and obesity variants) and modifiable lifestyle (diet, physical activity, smoking, alcoholExpand
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Neurosurgical intensive care
IntroductIon:Neuro hospital is the only hospital in eastern Nepal that has an Intensive care unit (ICU) dedicated to neurological surgery. This is a 6-bed ICU with four ventilators, Arterial bloodExpand
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Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials
Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weightExpand
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