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FtsN, a late recruit to the septum in Escherichia coli
The localization of FtsN in Escherichia coli was investigated by immunofluorescence microscopy and found to localize to the septum in a ring pattern similar to that observed for FtsZ and FtsA, although the frequency of cells with rings was less.
FtsZ ring formation in fts mutants
The formation of FtsZ rings in various fts mutants was examined and indicated that fully functional ftsA, ftsQ, and ftsI genes are not required for Z-ring formation and are unlikely to have a role in localization of the Z ring.
FtsA is localized to the septum in an FtsZ-dependent manner
Results suggest that the Z ring recruits FtsA to the septum in a ring pattern as previously shown for FtsZ, and in mutants where FTSZ forms structures in addition to Z rings, the pattern of Fts a duplicated these structures.
Molecular Evolution of FtsZ Protein Sequences Encoded Within the Genomes of Archaea, Bacteria, and Eukaryota
The FtsZ protein is a polymer-forming GTPase which drives bacterial cell division and is structurally and functionally related to eukaryotic tubulins and the existence of three ancestoral euryarchaeal FTSZ paralogues is suggested.
Bacterial cell division and the Z ring.
Evidence suggests that the Z ring is utilized by all prokaryotic organisms for division and may also be used by some eukaryotic organelles.
FtsZ polymer-bundling by the Escherichia coli ZapA orthologue, YgfE, involves a conformational change in bound GTP.
- Elaine Small, R. Marrington, +5 authors S. Addinall
- Biology, MedicineJournal of molecular biology
- 25 May 2007
The consequences of FtsZ polymer bundling by YgfE and divalent cations are very similar in terms of GTPase activity, bundle morphology and GTP orientation and therefore it is proposed that this conformational change in bound GTP reveals a general mechanism of FTSZ bundling.
ftsW is an essential cell‐division gene in Escherichia coli
- D. S. Boyle, M. Khattar, S. Addinall, J. Lutkenhaus, W. Donachie
- Biology, MedicineMolecular microbiology
- 1 June 1997
It is concluded that FtsW is an essential cell‐division protein in Escherichia coli, and that it plays a role in the stabilization of the FtsZ ring during cell division.
FtsZ‐spirals and ‐arcs determine the shape of the invaginating septa in some mutants of Escherichia coli
The data show that Z‐spirals and Z‐arcs can contract and that in doing so, they determine the shape of the invaginating septa, which strongly suggest that in normal cell division, FtsZ is positioned to a single nucleation site on the inner membrane, from which it polymerizes bidirectionally around the cell circumference.
Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects
It is shown that increased Stn1 levels affect growth of cells with telomere capping defects due to cdc13-1 and yku70Δ, and QFA is a sensitive, high-throughput method that will also be useful to understand other aspects of microbial cell biology.
Colonyzer: automated quantification of micro-organism growth characteristics on solid agar
- C. Lawless, D. Wilkinson, Alexander Young, S. Addinall, D. Lydall
- Computer Science, MedicineBMC Bioinformatics
- 28 May 2010
Colonyzer is a collection of image analysis algorithms for automatic quantification of the size, granularity, colour and location of micro-organism cultures grown on solid agar that can automatically quantify culture growth from large batches of captured images of microbial cultures grown during genome-wide scans.