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Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
Despite limited data supporting the superiority of dominant over subdominant responses, immunodominant epitopes represent the preferred vaccine candidates. To address the function of subdominant… Expand
Donor KIR Genes 2DL5A, 2DS1 and 3DS1 are associated with a reduced rate of leukemia relapse after HLA-identical sibling stem cell transplantation for acute myeloid leukemia but not other hematologic…
- K. Stringaris, S. Adams, +4 authors A. Barrett
- Biology of blood and marrow transplantation…
- 1 September 2010
Stem cell transplantation (SCT) from a healthy donor can be curative for patients with hematologic malignancies resistant to other treatments. Elimination of malignant cells through a… Expand
Extensive HLA class I allele promiscuity among viral CTL epitopes
- N. Frahm, K. Yusim, +26 authors C. Brander
- Biology, Medicine
- European journal of immunology
- 1 September 2007
Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I‐restricted epitopes exist. To address the extent of promiscuity… Expand
Phase I Trial of Intratumoral Injection of CCL21 Gene–Modified Dendritic Cells in Lung Cancer Elicits Tumor-Specific Immune Responses and CD8+ T-cell Infiltration
Purpose: A phase I study was conducted to determine safety, clinical efficacy, and antitumor immune responses in patients with advanced non–small cell lung carcinoma (NSCLC) following intratumoral… Expand
Primitive quiescent CD34+ cells in chronic myeloid leukemia are targeted by in vitro expanded natural killer cells, which are functionally enhanced by bortezomib.
Primitive quiescent CD34(+) chronic myeloid leukemia (CML) cells are more biologically resistant to tyrosine kinase inhibitors than their cycling counterparts; however, graft-versus-leukemia (GVL)… Expand
Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia
Natural killer (NK) cells are the first lymphocytes to recover after allogeneic stem cell transplantation (SCT) and can exert powerful graft-versus-leukemia (GVL) effects determining transplant… Expand
Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians.
OBJECTIVE To define the relative importance (RI) of class II major histocompatibility complex (MHC) alleles and peptide binding motifs as risk or protective factors for juvenile dermatomyositis (DM),… Expand
Integrating pharmacogenetic information and clinical decision support into the electronic health record
- B. Goldspiel, W. Flegel, +10 authors J. McKeeby
- Medicine, Computer Science
- J. Am. Medical Informatics Assoc.
- 1 May 2014
Pharmacogenetics (PG) examines gene variations for drug disposition, response, or toxicity. Expand
HLAMatchmaker-driven analysis of responses to HLA-typed platelet transfusions in alloimmunized thrombocytopenic patients.
This study describes a novel application of HLAMatchmaker to determine platelet compatibility in 16 alloimmunized patients with aplastic anemia refractory to random donor platelet transfusions.… Expand
Ambiguous allele combinations in HLA Class I and Class II sequence-based typing: when precise nucleotide sequencing leads to imprecise allele identification
- S. Adams, K. Barracchini, +5 authors D. Stroncek
- Biology, Medicine
- Journal of Translational Medicine
- 13 September 2004
Sequence-based typing (SBT) is one of the most comprehensive methods utilized for HLA typing. However, one of the inherent problems with this typing method is the interpretation of ambiguous allele… Expand