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Inhibitors of HIV-1 replication that inhibit HIV integrase
TLDR
The dicaffeoylquinic acids are promising leads to new anti-HIV therapeutics and offer a significant advance in the search for new HIV enzyme targets as they are both specific for HIV-1 integrase and active against HIV- 1 in tissue culture.
Dicaffeoylquinic acid inhibitors of human immunodeficiency virus integrase: inhibition of the core catalytic domain of human immunodeficiency virus integrase.
TLDR
The results indicate that the dicaffeoylquinic acids as a class are potent and selective inhibitors of HIV-1 IN and form important lead compounds for HIV drug discovery.
Epicatechin suppresses IL-6, IL-8 and enhances IL-10 production with NF-kappaB nuclear translocation in whole blood stimulated system.
TLDR
Results indicate that EC suppresses the production of pro-inflammatory cytokines, IL6 and IL-8, enhances theProduction of anti- inflammatory cytokine, IL-10, and stimulates NFkappaB p65 translocation to nucleus in PHA+LPS stimulated whole blood culture.
Assessment of zolpidem and Cl‐966 for anxiolytic and anxiogenic properties by using the discrimination of pentylenetetrazole by rats
TLDR
The present data suggest that the discriminative stimulus produced by PTZ is not related to its ability to produce convulsions, and the partial substitution of CI‐966 given in high doses is consistent with clinical reports that this compound may produce anxiogenic effects.
Inhibitors of HIV-1 replication [corrected; erratum to be published] that inhibit HIV integrase.
TLDR
Three dicaffeoylquinic acids are promising leads to new anti-HIV therapeutics and offer a significant advance in the search for new HIV enzyme targets as they are both specific for HIV-1 integrase and active against HIV- 1 in tissue culture.