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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
It is shown that A. muciniphila retains its efficacy when grown on a synthetic medium compatible with human administration and enhanced its capacity to reduce fat mass development, insulin resistance and dyslipidemia in mice, and Amuc_1100, a specific protein isolated from the outer membrane of A. Sydneyi, interacts with Toll-like receptor 2, is stable at temperatures used for pasteurization and partly recapitulates the beneficial effects of the bacterium. Expand
Microbial shifts and signatures of long-term remission in ulcerative colitis after faecal microbiota transplantation
A microbial ecosystem rich in Bacteroidetes and Proteobacteria and low in Clostridium clusters IV and XIVa observed in UC patients after FMT was predictive of poor sustained response, unless modified with a donor microbiota rich in specific members from the Clostridgeium clusters XIVa. Expand
Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function
Results indicate that outer membrane protein composition and particularly the newly identified highly abundant pili-like protein Amuc_1100 of A. muciniphila are involved in host immunological homeostasis at the gut mucosa, and improvement of gut barrier function. Expand
Action and function of Akkermansia muciniphila in microbiome ecology, health and disease.
This well studied member of the microbiota has been studied in three aspects that will be further described in this review: i) A. muciniphila characteristics and mucin adaptation, ii) its roles as key species in the mucosal microbiome, and iii) its role in host health. Expand
Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B12 Production by Intestinal Symbionts
The observed metabolic interactions between A. muciniphila and butyrogenic bacterial taxa support the existence of colonic vitamin and butyrate production pathways that are dependent on host glycan production and independent of dietary carbohydrates. Expand
Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study
T1D patients harbor a different amount of intestinal SCFA (butyrate) producers and different plasma acetate and propionate levels, which should disentangle cause and effect and whether supplementation of SCFA-producing bacteria or SCFA alone can have disease-modifying effects in T1D. Expand
Antibiotics-induced monodominance of a novel gut bacterial order
An undiscovered wealth of low abundant but common taxa in the human gut is pointed to and calls for more highly resolved longitudinal studies, in particular on ecosystem perturbations. Expand
Akkermansia glycaniphila sp. nov., an anaerobic mucin-degrading bacterium isolated from reticulated python faeces.
Based on phenotypic, phylogenetic and genetic characteristics, strain PytT represents a novel species of the genus Akkermansia, for which the name Akker mansia glycaniphila sp. Expand
A purified membrane protein from Akkermansia muciniphila
1 pasteurized bacterium improves metabolism in obese and diabetic mice 2 3 Hubert Plovier, Amandine Everard, Céline Druart, Clara Depommier, Matthias Van Hul, 4 Lucie Geurts, Julien Chilloux, NooraExpand
Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach
Findings show that the expression of mucolytic enzymes by A. muciniphila increases upon the presence of a community member, which could indicate its role as a keystone species that supports the microbial community in the mucosal environment by increasing the availability of mucin sugars. Expand