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HIV evolution: CTL escape mutation and reversion after transmission
Within-patient HIV evolution reflects the strong selection pressure driving viral escape from cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape mutationsExpand
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Mutualistic Polydnaviruses Share Essential Replication Gene Functions with Pathogenic Ancestors
Viruses are usually thought to form parasitic associations with hosts, but all members of the family Polydnaviridae are obligate mutualists of insects called parasitoid wasps. Phylogenetic dataExpand
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Microplitis demolitor Bracovirus Proviral Loci and Clustered Replication Genes Exhibit Distinct DNA Amplification Patterns during Replication
ABSTRACT Polydnaviruses are large, double-stranded DNA viruses that are beneficial symbionts of parasitoid wasps. Polydnaviruses in the genus Bracovirus (BVs) persist in wasps as proviruses, andExpand
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Extraction and characterization of chitin; a functional biopolymer obtained from scales of common carp fish (Cyprinus carpio l.): A lesser known source
Chitin is the most abundant natural amino polysaccharide and is estimated to be produced annually almost as much as cellulose. It has become of great interest not only as an industrialized resource,Expand
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Delivery of antihuman African trypanosomiasis drugs across the blood-brain and blood-CSF barriers.
Human African trypanosomiasis (HAT or sleeping sickness) is a potentially fatal disease caused by the parasite, Trypanosoma brucei sp. The parasites are transmitted by the bite of insect vectorsExpand
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Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease
Research into amisulpride use in Alzheimer’s disease (AD) implicates blood-brain barrier (BBB) dysfunction in antipsychotic sensitivity. Solute carrier function in AD has not been widely studied.Expand
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Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug
Human African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetseExpand