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Synthesis of benzothiazole semicarbazones as novel anticonvulsants--the role of hydrophobic domain.
A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesizedExpand
1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: synthesis and preliminary evaluation of biological properties.
Out of all tested compounds, the compounds 3, 7, 17 and 20, showed significant reduction in rat paw edema induced by carrageenan treatment and showed significant analgesic effect and at an equimolar oral doses relative to flurbiprofen were also found to be non-gastrotoxic in rats. Expand
N-{[(6-substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2/4-substituted benzamides: synthesis and pharmacological evaluation.
A series of 1,3-benzothiazol-2-yl benzamides prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity, CNS depressant study and other toxicity studies showed the decrease in the immobility time. Expand
Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain.
A series of sulphonamide derivatives were synthesized in good yield and evaluated for their possible anticonvulsant activity and neurotoxic study and all the compounds were less toxic than the standard drug phenytoin. Expand
Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.
Among the compounds studied, compound 2e showed more potent anti-inflammatory and analgesic activity than the standard drug, along with minimum ulcerogenic index. Expand
Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.
A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizureExpand
Biological Activities Of Sulfonamides
The present review highlights the recently synthesized sulfonamides possessing important potential biological activities and investigates whether new sulphonamide derivatives can be utilized as potent therapeutic agents in future. Expand
Biochemical analysis of fruiting bodies of Volvariella volvacea (local strain Vv pk) grown on six different substrates.
Cotton waste is recommended as an effective substrate to grow Chinese mushroom on commercial scale because of its high levels of protein, crude fibre and certain other elements. Expand
Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid.
Several derivatives of isoniazid derivatives were synthesized in satisfactory yield and pharmacologically evaluated for their anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities by known experimental models. Expand
Benzothiazoles: A new profile of biological activities
The small and simple benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess interesting biological activities, such as antitumor,Expand