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Synthesis of some novel benzoxazole derivatives as anticancer, anti-HIV-1 and antimicrobial agents.
In an effort to establish new candidates with improved antineoplastic, anti-HIV-1 and antimicrobial activities we report here the synthesis and in vitro biological evaluation of various series of
Synthesis of novel benzofuran and related benzimidazole derivatives for evaluation ofin vitro anti-HIV-1, anticancer and antimicrobial activities
It is concluded that the presence of the spacer between the heterocyclic substituent and the benzofuran nucleus may be essential for the biological activity.
Synthesis, anticancer, anti-HIV-1, and antimicrobial activity of some tricyclic triazino and triazolo[4,3-e]purine derivatives
In an effort to etablish new candidates with improved antineoplastic, anti-HIV-1 and antimicrobial activities, the synthesis of some new triazino and triazolo[4,3-e]purine derivatives is described:
New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.
New molecular hybrids combining benzothiophene or its bioisostere benzofuran with rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors and compound 5h showed physicochemical, ADMET, and drug-like properties within those considered adequate for a drug candidate.
Benzimidazole condensed ring systems. XII. Synthesis and anticancer evaluation of certain pyrido[1,2-a]benzimidazole derivatives.
The synthesis and antineoplastic evaluation of related series of PBIs with similar haloarylamino, haloARYlamino-3-phenyl-PBI and haloarylazo moieties at position 1 or 2 reveal notable activity against some tumor cell lines.
Synthesis of Some New Quinoxalines and 1,2,4‐Triazolo[4,3‐a]‐quinoxalines for Evaluation of in vitro Antitumor and Antimicrobial Activities
Preliminary screening at NCI showed that compounds 2b, 2c, 3b, 3c, and 9 exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10–6 to 10–5 molar concentrations, and in vitro microbiological data revealed that the prepared compounds showed mild antimicrobial activity.
Nonsteroidal antiinflammatory agents-part 2 antiinflammatory, analgesic and antipyretic activity of some substituted 3-pyrazolin-5-ones and 1,2,4,5,6,7-3H-hexahydroindazol-3-ones.
A structure-activity relationship (SAR) comparative study indicated that some compounds from 3-pyrazolin-5-one and indazolone series exhibited pronounced antiinflammatory, analgesic and antipyretic activities relative to indomethacin.
Synthesis and in vitro‐Anticancer and Antimicrobial Evaluation of Some Novel Quinoxalines Derived from 3‐Phenylquinoxaline‐2(1H)‐thione
Two novel series derived from 3‐phenylquinoxaline‐2(1H)‐thione 2 and 2‐(hydrazinocarbonylmethylthio)‐3‐phenylon 6 have been synthesized and preliminary antimicrobial testing revealed that compounds 7a, 7b, 8a, 11a, and 11b were as active as ampicillin against B. subtilis and P. aerugenosa.