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Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei in patients with type-1 diabetes mellitus.
It is suggested that type-1 diabetes mellitus is a condition with genomic instability characterized by an increased level of SCE, and Hyperglycemia-induced oxidative stress may be the underlying factor of the increased SCE frequency. Expand
Determination of the Phenolic Compounds and Antioxidative Capacity in Red Algae Gracilaria bursa-pastoris
Gracilaria bursa-pastoris can be utilized as a source of natural antioxidant molecules and could be useful for food industry. Expand
In vitro genotoxic effects of the anticancer drug gemcitabine in human lymphocytes.
It is indicated that gemcitabine is able to induce both cytotoxic and genotoxic effects in human lymphocyte cultures in vitro in a dose-dependent manner. Expand
Determination of the Anti-Oxidative Capacity and Bioactive Compounds in Green Seaweed Ulva rigida C. Agardh
There is an increasing demand for natural antioxidant molecules in order to replace the synthetic additives in the food industry. Therefore, Ulva rigida C. Agardh was analyzed to determine its… Expand
In vitro antigenotoxicity of Ulva rigida C. Agardh (Chlorophyceae) extract against induction of chromosome aberration, sister chromatid exchange and micronuclei by mutagenic agent MMC.
- S. Çelikler, G. Yıldız, O. Vatan, R. Bilaloğlu
- Biology, Medicine
- Biomedical and environmental sciences : BES
- 1 December 2008
Although URE itself is not a clastogenic or cytotoxic substance, it possesses strong antigenotoxic, anti-clastogenic, and protective effects on MMC in vitro. Expand
Parmelia sulcata Taylor and Usnea filipendula Stirt induce apoptosis‐like cell death and DNA damage in cancer cells
This work has investigated anti‐proliferative/apoptotic effects of methanolic extracts of lichen species Parmelia sulcata Taylor and Usnea filipendula Stirt on human lung cancer, liver cancer and rat glioma cells. Expand
Promising anticancer activity of a lichen, Parmelia sulcata Taylor, against breast cancer cell lines and genotoxic effect on human lymphocytes
- F. Ari, E. Ulukaya, S. Oran, S. Çelikler, S. Ozturk, M. Z. Ozel
- Biology, Medicine
- 1 May 2015
Results suggest that P. sulcata may induce caspase-independent apoptotic cell death at lower doses, while it may be genotoxic at relatively higher doses. Expand
A biomonitoring study of genotoxic risk to workers of transformers and distribution line stations
- S. Çelikler, N. Aydemir, O. Vatan, Sevim Kurtuldu, R. Bilaloğlu
- International journal of environmental health…
- 10 November 2009
It is demonstrated that a significant induction of cytogenetic damage in peripheral lymphocytes of workers engaged to occupational exposure to ELMF in electric transformer and distribution stations. Expand
6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor β1-enhanced invasion of Panc1 cells in vitro.
- A. Yalcin, T. H. Solakoglu, +7 authors J. Chesney
- Biology, Medicine
- Biochemical and biophysical research…
- 11 March 2017
PFKFB3 is identified as a key TGF β1 effector protein that mediates TGFβ1's effect on Snail expression, invasion, and glycolysis, and siRNA silencing of PFK FB3 prevents the stimulation of glycolynsis and in vitro invasive ability of Panc1 cells by TGFα1. Expand
Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis
- S. Ozturk, M. Erkisa, S. Oran, E. Ulukaya, S. Çelikler, F. Ari
- Medicine, Chemistry
- Drug and chemical toxicology
- 5 March 2019
Usnea intermedia was especially cytotoxic against MDA-MB-231 and H1299 cells, resulted from apoptosis, and warrants for further in vivo evaluation as a new alternative in cancer treatment. Expand