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The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl
TLDR
The pharmacodynamics and pharmacokinetics of a new non-depolarizing neuromuscular blocking agent, Org 9426, were investigated and it is concluded that the difference in potency between Org 9326 and vecuronium is similar to the difference between their effective concentrations. Expand
Clinical observations on the neuromuscular blocking action of Org 9426, a new steroidal non-depolarizing agent.
TLDR
Org 9426 may have advantages over existing non-depolarizing neuromuscular blocking agents with respect to rate of development of good intubating conditions, and is stable in aqueous solutions. Expand
Effects of 4-aminopyridine in Eaton Lambert Syndrome.
The effects of 4-aminopyridine (a non-anticholinesterase antagonist of curare-like agents) on the evoked muscle action potentials (EMAP) in a patient with Eaton Lambert Syndrome are reported. On twoExpand
Comparative Pharmacokinetics and Dynamics of Vecuronium and Pancuronium in Anesthetized Patients
TLDR
In spite of its greater potency, vecuronium has a shorter duration of action than pancuronium; this was reflected in a significantly larger plasma clearance rate for veCuronium (4 ml·min−1·kg−1 vs 1.1 ml·Min−1 for Pancuronium). Expand
Preliminary investigations of the clinical pharmacology of three short-acting non-depolarizing neuromuscular blocking agents, Org 9453, Org 9489 and Org 9487
TLDR
Org 9453 and Org 9487 are short-acting muscle relaxants in humans, and a moderate short-lasting decrease of blood pressure and a concomittant increase in heart rate were noted. Expand
Pharmacokinetics and Pharmacodynamics of Vecuronium and Pancuronium in Anesthetized Children
TLDR
The pharmacokinetics and pharmacodynamics of vecuronium and pancuronium were determined in 12 children undergoing minor surgery under 60% nitrous oxide, 1 MAC halothane anesthesia and no metabolites could be detected in plasma. Expand
The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 in the cat.
TLDR
The neuromuscular blocking effects and pharmacokinetics of ORG 9426 and ORG 9616 and its desacetyl metabolites in plasma, urine, bile, and liver were studied in 28 cats with and without renal pedicle ligation. Expand
The influence of hypothermia (surface cooling) on the time-course of action and on the pharmacokinetics of rocuronium in humans.
TLDR
It is concluded that hypothermia prolongs the duration of action of rocuronium and delays spontaneous recovery and that altered pharmacokinetics, such as a decreased clearance, play an important role in this. Expand
Pancuronium pharmacokinetics in patients with liver cirrhosis.
TLDR
The results suggest that there is a risk of prolonged duration of action of pancuronium in patients with cirrhosis, and in these patients, the initial dose to achieve adequate muscle relaxation is high and simultaneously there is slow disappearance of Pancuronium from plasma. Expand
A NEW METHOD FOR STUDYING THE RELATIONSHIP BETWEEN HEPATIC UPTAKE OF DRUGS AND THEIR PHARMACODYNAMIC EFFECTS IN ANAESTHETIZED CATS
TLDR
The liver appears to tolerate short periods of hepatic exclusion and it is concluded that this technique may become a useful tool for studying the handling of drugs by this organ. Expand
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