Learn More
UV-induced DNA damage causes repression of RNA synthesis. Following the removal of DNA lesions, transcription recovery operates through a process that is not understood yet. Here we show that knocking-out of the histone methyltransferase DOT1L in mouse embryonic fibroblasts (MEF(DOT1L)) leads to a UV hypersensitivity coupled to a deficient recovery of(More)
In nucleotide excision repair (NER), damage recognition by XPC-hHR23b is described as a critical step in the formation of the preincision complex (PInC) further composed of TFIIH, XPA, RPA, XPG, and ERCC1-XPF. To obtain new molecular insights into the assembly of the PInC, we analyzed its formation independently of DNA damage by using the lactose(More)
Modern manufacturing facilities are large scale, highly complex, and operate with large number of variables under closed loop control. Early and accurate fault detection and diagnosis for these plants can minimise down time, increase the safety of plant operations, and reduce manufacturing costs. Fault detection and isolation is more complex particularly in(More)
A new approach for fault detection and monitoring based on the parameters identification coupled to the Principal Component Analysis (PCA) is proposed in this paper. The proposed Fault Detection and Monitoring consists to apply the PCA method on the dynamic of the identified parameters. Conventional PCA uses the process inputs and outputs as variables which(More)
— On-line vibration monitoring of Rotary Machines is a fundamental axis of development and industrial research. Its purpose is to provide knowledge about the working condition of machines at each moment without stopping the production line. This method allows avoiding the production losses related to breakdowns and reducing overall maintenance costs.(More)
  • 1