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A previous study showed that BMP-2 (bone morphogenetic protein-2) and wear debris can separately support osteoclast formation induced by the receptor activator of NF-κB ligand (RANKL). However, the effect of BMP-2 on wear debris-induced osteoclast formation is unclear. In this study, we show that neither titanium particles nor BMP-2 can induce osteoclast(More)
Wear particles are phagocytosed by macrophages and other inflammatory cells, resulting in cellular activation and release of proinflammatory factors, which cause periprosthetic osteolysis and subsequent aseptic loosening, the most common causes of total joint arthroplasty failure. During this pathological process, tumor necrosis factor-alpha (TNF-α) plays(More)
We demonstrate an intense broadband terahertz (THz) source based on the interaction of relativistic-intensity femtosecond lasers with aligned copper nanorod array targets. For copper nanorod targets with a length of 5 μm, a maximum 13.8 times enhancement in the THz pulse energy (in ≤20 THz spectral range) is measured as compared to that with a thick plane(More)
S. Sen , F. Wang , S. Sun , T. J. Magliery , P. G. Schultz 4 1 WIL Research Laboratories, LLC, 2 Scripps Research Institute, 3 Ohio State University, 4 The Scripps Research Institute Purpose Affinity maturation involves production of matured antibodies that has increased specific affinity towards an antigen duri the course of an immune response, brought(More)
Anthrone-sulfuric acid assay, a rapid, sensitive microanalytic method, was modified to quantify carbohydrate in a colorimetric tube. A single test methodology was applied to design and optimize the factors including solvents, heating, anthrone concentration, sulfuric acid concentration, amount of anthrone reagent and reaction duration. The tube with the(More)
Single crystals of Zinc Tris (thiourea) Sulphate (ZTS) exhibiting high transparency were grown by slow evaporation technique. Single crystal X-ray diffraction analysis reveals that the crystal belongs to orthorhombic system. The optical absorption study reveals the transparency of the crystal and is noticed in the entire visible region and the cut-off(More)
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