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Idiopathic Parkinson's disease (PD) is characterized by loss of dopaminergic terminals in the basal ganglia. The cocaine analog, CFT (WIN 35,428), has been shown to bind selectively to the pre-synaptic dopamine transporters and thus represents an important probe for monitoring disease progression. In this study, we evaluated [11C] labeled CFT as a PET(More)
OBJECTIVE To localize a gene predisposing to benign epilepsy of childhood with centrotemporal spikes (BECTS). BACKGROUND BECTS, or rolandic epilepsy, is the most prevalent idiopathic epilepsy syndrome in childhood. Functional relevant defects in the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor (AChR) have been demonstrated in autosomal(More)
The limits of quantitation with positron emission tomography (PET) are examined with respect to the noise propagation resulting from radioactive decay and other sources of random error. Theoretical methods for evaluating the statistical error have been devised but seldom applied to experimental data obtained on human subjects. This paper extends the(More)
  • S Weise, U Scholz, M S Röder, I E Matthies
  • 2009
MetaBrew is a manually curated and comprehensive repository of high quality analysis data concerning kernel, malting and brewing quality of barley cultivars. This includes meta information about the genotypic and phenotypic background (pedigree, row number, seasonal habit, environment, experiment sources). Exploration and export of the information is(More)
BACKGROUND The prevalence of chronic headaches in children and adolescents is up to 2 % resulting in the beginning of the later typical headache careers of adults. The therapy for chronic migraine with botulinum toxin is now established in adults. However, there is only limited experience in the use of botulinum toxin in paediatric patients. METHODS 10(More)
  • E Grafahrend-Belau, B H Junker, D Koschützki, C Klukas, S Weise, U Scholz +1 other
  • 2008
Modeling of plant metabolism offers new approaches to improve the understanding of complex biological processes. In this paper we present a framework for the constraint-based stoichiometric analysis of crop plant metabolic models , which combines tools for (1) model reconstruction, (2) model analysis (i.e. flux balance analysis), and (3) model(More)
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