S. Webster

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Interleukin-8/CXCL8 (IL-8) is a chemokine and angiogenic factor. Recently, IL-8 was identified as an autocrine growth factor in several human cancers. Here, we investigated the expression and function of IL-8 in lung cancer cells. The expressions of IL-8 and its receptors, CXCR1 and CXCR2, were examined in a panel of non-small cell lung cancer (NSCLC) and(More)
1. The influence of salinity, temperature and physiological development on habitat choice by juvenile salmon is poorly understood. We measured differences in the net energetic cost of habitats that differed in salinity or temperature using behavioural titration of juvenile salmon and correlated these costs with body size and osmoregula-tory enzyme activity(More)
The energetic cost for juvenile Chinook salmon Oncorhynchus tshawytscha to forage in habitats of different salinity and depth was quantified using a behavioural titration based on ideal free distribution theory. When given a choice between freshwater habitats of different depths (>0Á83 or <0Á83 m), a greater proportion of fish used the deeper habitat. When(More)
Osteoporosis is responsible for a significant burden both individually and socially, but is readily treated with antiresorptive agents and mineral supplementation. However, long-term usage of these agents, notably bisphosphonates, is rarely associated with atypical fractures. Denosumab is a monoclonal antibody that reduces osteoclast activity and thus(More)
BACKGROUND Targeted therapies elicit anticancer activity by exerting pharmacodynamic effects on specific molecular targets. Currently, there is limited use of pharmacodynamic assessment to guide drug administration in the routine oncology setting. METHODS We developed a phosphoshift (pShift) flow cytometry-based test that measures RAF signal transduction(More)
Organic/inorganic matrix nanocomposites have been created using an acid catalyzed, tetraethyl orthosilicate-based sol–gel technique with single-walled carbon nanotubes (SWNTs). By utilizing nanotubes functionalized with the dendron methyl 3,5-di(meth-yltrigycoloxy)benzylic alcohol (I PEG), ultrasonic blending in the sol phase prior to gela-tion yields(More)