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BACKGROUND Lysosome associated protein transmembrane 4 beta (LAPTM4B) was identified first as a novel gene overexpressed in human hepatocellular carcinoma. LAPTM4B*1 and LAPTM4B*2 are two alleles of the gene; they are differentiated at 5'UTR in the first exon. Allele *1 contains only one copy of a 19-bp sequence in the 5'UTR. However, allele *2 contains(More)
BACKGROUND The overexpression of HER-2/neu oncogene has been implicated in the development and modulation of many types of cancer. However, whether HER-2/neu overexpression plays a similar role in hepatocellular carcinoma (HCC) has not been determined. METHODS Tissue specimens from 36 HCC patients who had been enrolled in 3 separate prospective clinical(More)
A case of alveolar soft part sarcoma arising some 20 years later in a site previously irradiated as a treatment for a spinal cord hemangioma is described. This is the first known case of radiation-associated alveolar soft part sarcoma, and it fulfills the criteria for a tumor to be radiation-induced. The coincidental finding of "viral-like" particles within(More)
A 25-year-old male patient with a biphasic synovial sarcoma of his right flank is reported. The tumor was not only richly glandular but also showed a rare finding in association with a sarcoma, namely, squamous differentiation. Light microscopy and electron microscopy demonstrated the classical features of a biphasic synovial sarcoma except for foci of(More)
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