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UNLABELLED Serum calcitonin and carcinoembryonic antigen (CEA) are markers of recurrent or persistent disease in medullary thyroid cancer (MTC). However, conventional imaging often fails to localize metastatic disease. Our aim was to compare fluorine-labeled dihydroxyphenylalanine ((18)F-DOPA) and (18)F-FDG PET/CT with multidetector CT (MDCT) and MRI in(More)
BACKGROUND AND PURPOSE The m.3243A>G mutation is the most common pathogenic mutation in mtDNA; tissues with high dependence on aerobic energy metabolism, such as the brain, heart, and skeletal muscle, are most affected by the ensuing mitochondrial dysfunction. We hypothesized that the m.3243A>G mutation manifests as disturbances in white matter(More)
The m.3243A>G mutation is the most common pathogenic mutation in mitochondrial DNA. It leads to defective oxidative phosphorylation, decreased oxygen consumption and increased glucose utilization and lactate production in vitro. However, oxygen and glucose metabolism has not been studied in the brain of patients harbouring the m.3243A>G mutation. Therefore,(More)
IMPORTANCE Evidence from preclinical models indicates that xenon gas can prevent the development of cerebral damage after acute global hypoxic-ischemic brain injury but, thus far, these putative neuroprotective properties have not been reported in human studies. OBJECTIVE To determine the effect of inhaled xenon on ischemic white matter damage assessed(More)
The formation of vortices by topological phase engineering has been realized experimentally to create the first two- and four-quantum vortices in dilute atomic Bose-Einstein condensates. We consider a similar system, but in addition to the Ioffe-Pritchard magnetic trap we employ an additional hexapole field. By controlling cyclically the strengths of these(More)
The formation of quantized vortices in trapped, gaseous Bose-Einstein con-densates is considered. The thermodynamic stability of vortex states and the essential role of the surface excitations as a route for vortex penetration into the condensate are discussed. Special focus is on finite-temperature effects of the vortex nucleation process. It is concluded(More)
Obstructive sleep apnoea (OSA) is associated with atherosclerosis and cardiovascular events. Peripheral arterial disease (PAD) represents severe atherosclerosis with a high mortality after vascular surgery. The role of OSA in the prognosis of these patients is not yet established. 84 patients (aged 67 ± 9 years) scheduled for sub-inguinal surgical(More)