S. Viktor Varga

Learn More
AIMS To evaluate a recently developed digital slide and virtual microscope system, and to compare this method with optical microscopy on routine gastrointestinal biopsy specimens in both local and remote access modes. METHODS A fully computer controlled commercial microscope was used. The scanning program included object detection, autofocus, and image(More)
The enormous amount of clinical, pathological, and staining data to be linked, analyzed, and correlated in a tissue microarray (TMA) project makes digital slides ideal to be integrated into TMA database systems. With the help of a computer and dedicated software tools, digital slides offer dynamic access to microscopic information at any magnification with(More)
The concentration of testosterone and estradiol in the blood plasma and the binding capacity of testosterone-estradiol binding globulin (TEBG) were studied in 30 women and 6 men with Icenko-Cushing's disease in the active phase and in 24 women with hormonally active adrenal tumors. In hypercorticism against a background of unchanged of lowered concentration(More)
Nonsteroid antiandrogen 4-nitro-3-trifluoromethylisobutyranilide (10 mg/kg per os from the 26th to the 37th day after birth) decreased the weight of the accessory sex organs, and levator ani muscle. DNA, RNA, and protein content in the ventral prostate and the seminal vesicles, the thickness of the secretory cell epithelium of the ventral prostate under(More)
In experiments on rats and guinea pigs is shown the capability of the synthetized nesteroid antiandrogen--4-nitro-3-trifluormethylisobutyranilide (niftholide) to block the stimulating effect of exogenous and endogenous testosteon on the prostate, seminal vesicles and levator ani muscle. The results of histological and morphometric investigations bear proof(More)
Experiments on intact mature male Wistar rats showed the ability of hydroxyniftolide (4'-nitro-3'-trifluoromethyl-2-hydroxy-2-methylpropionylanilide), a hydroxylated antiandrogen derivative of niftolide, to inhibit the effects of male sex hormones in androgen target organs. At doses of 10 mg/kg and upwards administered intravenously or intramuscularly for(More)
Ten-month-old male rats thymectomized in early post-puberty were ascertained to have lower plasma luteinizing and testicular hormones and higher testicular steroid dehydrogenase activity. Following 24 hours of administration of a thymocyte membrane structural agent, pituitary gonadotropic and gonadal androgenic functions became normal. There was no(More)
Antlandrogen activity (the ability to suppress the action of the male sex hormones) is known to be a characteristic of many natural and synthetic substances having a steroid structure. Some of these substances (e.g., cyproterone acetate) have come to be used in medical practice to treat androgen-dependent diseases, such as prostate gland tumors, ache,(More)
The effects of low doses of hexestrol (Hex) (2-40 micrograms/kg bw) and flutamide (FI) (10 mg/kg bw) on some endocrine mechanisms in mature intact male rats are described in the present paper. It has been shown that each preparation, administered separately for 10 days, induced a moderate decrease in the weight of the ventral prostate (VP), anterior(More)