The EEG effects of intake of the mean therapeutic single dose of cholinomimetic amiridin (20 mg) or cholinolytic amizyl (2 mg) were studied in 7 healthy subjects. After the intake of the drugs with agonistic and antagonistic action, significant opposite changes in the EEG spectral density were observed in the frequency ranges of 0.6-6.7, 7.7-11.4, and… (More)
Pharmacogenous shifts in EEG spectral density induced by mutually antagonistic noradrenotropic influences (pairs sydnocarb-obsidan and sydnocarb-sonapax) were compared in each of four subjects by means of factor and discriminant analysis. Narrow-band oppositely directed reactions were revealed almost in all classical EEG diapasons in a range of 0.5-30 Hz.… (More)
Patients with asthenic disorders were examined for EEG reactions to the administration of some nootropics. The significance of the narrow bands of the post-drug EEG spectrum was revealed. According to these data, the detailed EEG profiles of the nootropics under study were obtained. Analysis of these EEG profiles discovered the common and specific… (More)
To find EEG-markers of catecholaminergic activation shifts EEG power spectra of white rats were computed before and after intraperitoneal injections of propranolol, metaproterenol, haloperidol, amantadine, or isotonic sodium chloride solution. Differential spectral characteristics were undergone to factor analysis and discriminant analysis. Factors with… (More)
At pharmaco-electroencephalographic examination of patients with neuroses narrow-band components was carried out of the EEG spectrum, which oppositively changed under the influence of sidnocarb and obsidan--agonist and antagonist of noradrenergic system, the initial hypothesis on the perspectivity of search of the EEG markers of the level of activation of… (More)
Spatial EEG factor analysis was performed in patients under gamonil and damilen treatment. Groups of EEG-factors were discovered that describe the peculiarities of the brain electrical processes spatial reorganization under pharmacotherapy. Major groups comprised the EEG factors: 1. characterizing the proper action of the drug; 2. connected to the syndromal… (More)
Methods of factorial and discriminant analysis were used for the analysis of the electroencephalographic reaction to gamonil and damilen. Specific features of EEG spatial reorganization were revealed for each of the thymoleptics which made it possible to recognize correctly the drugs in 87.5 and 92.3% of cases, respectively.
The electroencephalographic reactions to stelazine, aminazine and haloperidol were studied by the methods of multifactor and multidiscriminant analyses. The specific features of pharmacogenic spatial reorganization of the EEG were revealed for every neuroleptic which made it possible to recognize the drugs in 90.9, 88.9 and 82.9% of cases, respectively.