Learn More
Living cells are controlled by quantum regulators in which the price of action of elementary operations approaches Planck's constant. The description of such systems is based on four principles: (1) minimal price of action principle for control; (2) principle of optimality; (3) minimum irreversibility principle; and (4) the principle of causality.
Depolarization of neuron membrane was shown to occur during cAMP injection by means of both iontophoresis and pressure. Distension of the neuron by means of blowing with large volumes of solution without cAMP can produce reversible responses. The time course can be made similar to that of the cAMP effect and the responses can be repeated many times in the(More)
The depolarization of neuronal membrane during cAMP injection by means of both iontophoresis and pressure was shown. Neuron blowing by solutions without cAMP gave the similar effect. The effect of cAMP can be differentiated in the presence of phosphodiesterase inhibitors. The experiments support the hypothesis that cyclic nucleotides and mechanical(More)
Cyclic 3',5'-AMP and cyclic 3',5'-GMP injected into large neurons of the snail Helix lucorum altered neuron activity. The effect of cAMP is usually depolarizing and that of cGMP hyperpolarizing. The results are specific for 3',5'-cyclic nucleotides. The experiments support the hypothesis that reaction-diffusion processes involving cyclic nucleotides form(More)
Intracellular microiontoforetic injections of cyclic 3',5'-AMP and cyclic 3',5'-GMP elicit different responses in the same neuron. Drugs were injected by current of 1--10 nA using 3-barrel micropipettes. Unlike cyclic 3',5'-AMP arising the depolarization of the neuron, cyclic 3',5'-GMP usually hyperpolarizes it. An inhibitor of phosphodiesterases,(More)
It is proposed to unite the principles of new science mathematics, physics and biology for the description of living creatures. Such description is based on four principles: minimal price of action, optimum prediction, minimal irreversibility, and causality. In this new knowledge of nature not only the molecular biological experimental aspects have to be(More)
Investigation of the influence of cAMP on neuronal electric activity suggests that nerve cells can solve problems using an intraneuronal calculating medium based on the cytoskeleton. When a new problem is posed, this structure has to be disassembled and assembled by the neuronal molecular computer according to the program recorded in DNA. If DNA lacks an(More)
Cyclic nucleotide injection in neurons shows that cAMP controls a new type of membrane permeability. The neuron response to cAMP has a short delay, unusual bioenergetics and is blocked by drugs binding with the regulatory subunit of protein kinase. These data are interpreted in terms of the hypothesis that the controlling system of the living cell is a(More)